The comparison of effects of toluene, especially noise and toluene along with noise per Auditory Brain Stem response on rabbit

Ali Khavanin; seyed bagher mortazavi; R Mirzaii; H Imani; Yaghoub  Fathollahi; Anoshirvan  Kazemnejad; M Akbary

Zahedan Journal of Research in Medical Sciences

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The comparison of effects of toluene, especially noise and toluene along with noise per Auditory Brain Stem response on rabbit

Author(s):

Ali Khavanin¹,

seyed bagher mortazavi¹,

R Mirzaii^2,*,

H Imani³,

Yaghoub Fathollahi⁴,

Anoshirvan Kazemnejad⁴,

M Akbary⁵

1Dept of Proportional Health, Faculty of Medicine, Tarbiyat Modarres University of Medical Sciences and Health Services Tehran, Iran.

2Dept of Proportional Health, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services Zahedan, Iran.

3Dept of Anatomy, Faculty of Medicine, Baghiyat Allah University of Medical Sciences and Health Services Tehran, Iran.

4Dept of Biostatics, Faculty of Medicine, Tarbiyat Modarres University of Medical Sciences and Health Services, Tehran, Iran.

5Dept of Audiometry, Faculty of Medicine, Iran University of Medical Sciences and Health Services Tehran, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 9, issue 3; e94789

Published online:Aug 11, 2007

Article type:Research Article

Received:Jun 28, 2007

Accepted:Jul 27, 2007

How to Cite:Khavanin A, mortazavi SB, Mirzaii R, Imani H, Fathollahi Y, et al. The comparison of effects of toluene, especially noise and toluene along with noise per Auditory Brain Stem response on rabbit. Zahedan J Res Med Sci. 2007;9(3):e94789. doi:

Abstract

Background: An increase more than definite limit in sound pressure level is harmful for health,
mean while, organic solvents like toluene are used in industrial processes with noise widely. So, this
study was going to investigate the relationship between toluene (1000 ppm), noise and toluene
along with noise (frequencies 4000 and 8000 Hz) per auditory Brain Stem response (ABR) on
rabbits being exposed to these contaminants.
Materials and Methods: This survey was done in experimental method on 48 three months old,
male adult white New Zealand rabbits (1800±200 g body weight), in nine groups which were
exposed to toluene(1000 ppm), noise (4000Hz), 100 dB SPL, combination of toluene and noise
(4000Hz), noise (8000Hz) and combination toluene and noise (8000Hz). ABR test measurement was
conducted using click and tone burst stimuli in 110dB sound pressure level. Then the results of ABR
test of groups exposed were analyzed by SPSS software. One-way variance (ANOVA) analysis was
used to compare the groups and Tukey test was applied as a post hoc test for comparison among
the groups. P values were obtained by Tukey test. t-test was conducted for comparison of ABR test
results after and before exposing groups. Differences at the level of P<0.05 were considered
statistically significant.
Results: The results of the study showed that Exposing rabbit's to combination of toluene and
noise caused hearing impairment in all of frequencies auditory especially in frequencies 250, 500
and 1000Hz. So that, wave five in ABR test (tone burst stimuli) didn’t formed in 250-1000Hz
frequencies. The mean of latency time of V wave (5 wave) were as follows; In control group
4.84±0.07ms, group exposed to toluene 5.18±0.07ms, noise group (4000Hz) 5.5±0.07ms and in
combination noise and toluene group (4000Hz) 5.79±0.07 ms. The mean of latency time of V wave
in control was compared to that of group noise group P=0.01, toluene group P=0.07 and
combination noise and toluene group P=0.0001.
Conclusion: According to the result of this study, Both toluene and noise exposure caused the
rabbits in hearing impairment but combination of toluene and noise exposure in frequencies of
4000 Hz and 8000Hz was much worse than hearing impairment. So that, the ABR test on rabbits
didn't formed V wave in low frequency.

Keywords

Auditory Brainstem Response

Rabbit

Toluene

Noise

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References

1.
The References of this article are available on the PDF file.

Effect of different exposure times to compliance noise on rabbits’ hearing protection by distortion product oto acoustic emissions

A Khavanin,

M Soleimani,

M Akbari,

R Mirzaaie,

S Nazari,

M Motalebi

Khavanin A, Soleimani M, Akbari M, Mirzaaie R, Nazari S, et al. Effect of different exposure times to compliance noise on rabbits’ hearing protection by distortion product oto acoustic emissions. J Inflamm Dis. 2024;17(1):e155739. doi:

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The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs

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Akram Pourbakht,

Ahmadreza Raisi,

Mohammad Kamali,

Mohammad Faridan

Bagheri F, Pourbakht A, Raisi A, Kamali M, Faridan M. The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs. Health Scope. 2018;7(4):e55353. doi: https://doi.org/10.5812/jhealthscope.55353

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Effect of Contemporary Exposure to Mixed Organic Solvents and Occupational Noise on Hearing Thresholds of Workers

Saber Mohammadi,

Yaser Labafinejad,

Azadeh Amiri Rigi,

Mirsaeed Attarchi

Mohammadi S, Labafinejad Y, Amiri Rigi A, Attarchi M. Effect of Contemporary Exposure to Mixed Organic Solvents and Occupational Noise on Hearing Thresholds of Workers. Zahedan J Res Med Sci. 2010;11(4):e94356. doi:

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2006

Effect of sound conditioning on protection of hearing and plasma antioxidant activity in rabbits

AA Allameh,

R Mirzaii,

SB Mortazavi,

A .Khavanin,

A .Kazemnejad,

M Akbary

Allameh A, Mirzaii R, Mortazavi S, .Khavanin A, .Kazemnejad A, et al. Effect of sound conditioning on protection of hearing and plasma antioxidant activity in rabbits. J Inflamm Dis. 2024;9(4):e155161. doi:

22

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Effects of Exposure to Cigarette Smoke on Distortion-Product Otoacoustic Emissions in Rats

Raheleh Hashemi Habybabady,

Seyed Bagher Mortazavi,

Ali Khavanin,

Ramazan Mirzaei

Hashemi Habybabady R, Mortazavi SB, Khavanin A, Mirzaei R. Effects of Exposure to Cigarette Smoke on Distortion-Product Otoacoustic Emissions in Rats. Health Scope. 2017;6(3):e15175. doi: https://doi.org/10.5812/jhealthscope.15175

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Author(s):

Ali Khavanin:[PubMed][Scholar]
seyed bagher mortazavi:[PubMed][Scholar]
R Mirzaii:[PubMed][Scholar]
H Imani:[PubMed][Scholar]
Yaghoub Fathollahi:[PubMed][Scholar]
Anoshirvan Kazemnejad:[PubMed][Scholar]
M Akbary:[PubMed][Scholar]

The Official Journal of Zahedan University of Medical Sciences

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The comparison of effects of toluene, especially noise and toluene along with noise per Auditory Brain Stem response on rabbit

Abstract

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