The Immunologic Response to Anti-Hepatitis B Vaccination Among Medical Students of Guilan University of Medical Sciences, Guilan, Iran

1Associate Professor of Gastroenterolology & Hepatology, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, [email protected], Gilan, IR.Iran

2PhD in Genetics, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Gilan, IR.Iran

Hepatitis Monthly:Vol. 6, issue 2; 63-66

Published online:Dec 31, 2006

Article type:Research Article

Received:May 01, 2006

Accepted:May 15, 2006

How to Cite:Ghanaei F, Fallah M, Jafarshad R, Joukar F, Arami M, et al. The Immunologic Response to Anti-Hepatitis B Vaccination Among Medical Students of Guilan University of Medical Sciences, Guilan, Iran. Hepat Mon. 2006;6(2):. doi:

Abstract

Background and Aims: An important way to prevent hepatitis B infection is vaccination especially among high-risk populations including healthcare workers. Unfortunately, immunologic response to the vaccine is not perfect. Multiple different factors such as gender, age, body mass index (BMI), smoking and underlying diseases can influence the immunologic response. So, this study was conducted to evaluate the post-vaccination immunologic response of medical students of Guilan University of Medical Sciences (GUMS).
Methods: In this cross-sectional study, GUMS medical students who had received complete vaccine series at zero, one, and six months were enrolled. Their demographic data and the factors which could probably alternate the immunologic response were collected by interview. The anti-HBs Ab titer was evaluated by Enzyme-Linked-Immunoassay (ELISA). Appropriate immunologic response was supposed to be HBsAb >=10 mIU/ml. The collected data were analyzed using SPSS 10.00.P value <0.05 was considered significant.
Results: We evaluated 233 students with mean age of 24.9¡4.5 years. 74.7% were female. 4.9% did not respond properly to vaccination. Females' immunologic responses were significantly higher than males' (P=0.001). Responsiveness was significantly lower in smokers than non-smokers (P=0.02). Mean age in inappropriate and appropriate responder groups were 28.67¡5.4 and 24.77|¡|4.4 years, respectively (P=0.004).
Conclusions: 95.1% of students had a protective level of anti-HBsAb (>10 mIU/ml). Since health-care staffs including medical students are a high risk group to be contaminated with HBV, it is preferable to be evaluated for anti-HBs titer 1-3 months after full three-dose vaccination especially when these factors are present; in this way the false sense of
being immunized among them may be decreased.

Keywords

Medical Students

Anti-HBV Antibody

Vaccination

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 6 days ago
Scopus by Title: 0
Last Update: 6 days ago
Scopus by Title (Ref): 0
Last Update: 6 days ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

F. Ghanaei:[PubMed][Scholar]
M Fallah:[PubMed][Scholar]
R. Jafarshad:[PubMed][Scholar]
F. Joukar:[PubMed][Scholar]
M. Arami:[PubMed][Scholar]
A. Ale-ESmaeil:[PubMed][Scholar]
M. Hoseinzadeh:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

The Immunologic Response to Anti-Hepatitis B Vaccination Among Medical Students of Guilan University of Medical Sciences, Guilan, Iran

Abstract

Full Text

Last Update: 6 days ago

Last Update: 6 days ago

Last Update: 6 days ago

Last Update: 3 days ago