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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Progress in Understanding the Calcium and Vitamin D Endocrinology Following Burn Injury in Children
Authors
1Orthopaedic Surgery and Rehabilitation Department, Medical Staff, Shriners Burns Hospital, University of Texas Medical Branch, Galveston, Texas, USA
*Corresponding Author: Gordon L Klein, Shriners Burns Hospital, Medical Staff Office, 815 Market Street, Galveston, Texas 77550, USA. Tel: +1- 4097706733, Fax: +1-4097706719, E mail: Email: [email protected]
Published online:Jan 31, 2012
Article type:Brief Report
Received:Oct 10, 2011
Accepted:Nov 30, 2011
How to Cite:L Klein G. Progress in Understanding the Calcium and Vitamin D Endocrinology Following Burn Injury in Children. Int J Endocrinol Metab. 2012;10(1):. doi: https://doi.org/10.5812/ijem.2685
Abstract
This review covers the progress made by our group over the past two decades in understanding the effects of severe burn injuries on the endocrine system, especially in relation to calcium and vitamin D metabolism.We examine the phenomena of transient growth hormone deficiency and the dose-dependent effects of recombinant human growth hormone on bone and muscle mass. We move on to discuss the occurrence of post-burn secondary hypoparathyroidism caused by the up-regulation of the parathyroid calcium-sensing receptor, and finally, we discuss vitamin D status, the progressive nature of vitamin D deficiency post-burn, the causes of the progressive deficiency, and what must be done to prevent it.These conditions taken together, while not primarily responsible for post-burn bone loss, may impair the recovery of normal bone density and leave, especially younger populations of victims, vulnerable to a reduction in peak bone mass with subsequent elevated risk of developing osteoporosis as adults.
Copyright © 2012 Kowsar M. P. Co. All rights reserved.
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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