Presepsin (Scd14) as a Marker of Serious Bacterial Infections in Chemotherapy Induced Severe Neutropenia

Hossein  Esfahani; Elham  Olad; Iraj  Sedighi; Azim  Mehrvar; Maryam  Tashvighi; Vahid  Fallahazad; Amirabbas  Hedayatiasl

Innovative Journal of Pediatrics

The Scientific Journal of Growth & Development Research Center

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Presepsin (Scd14) as a Marker of Serious Bacterial Infections in Chemotherapy Induced Severe Neutropenia

Author(s):

Hossein Esfahani^1,*,

Elham Olad²,

Iraj Sedighi³,

Azim Mehrvar⁴,

Maryam Tashvighi⁵,

Vahid Fallahazad⁶,

Amirabbas Hedayatiasl⁷

Innovative Journal of Pediatrics:Vol. 24, issue 6; 715-722

Published online:Nov 28, 2014

Article type:Research Article

Received:Jan 28, 2014

Accepted:Oct 01, 2014

How to Cite:Hossein Esfahani, Elham Olad, Iraj Sedighi, Azim Mehrvar, Maryam Tashvighi, et al. Presepsin (Scd14) as a Marker of Serious Bacterial Infections in Chemotherapy Induced Severe Neutropenia.Inn J Pediatr.2014;24(6):715-722.

Abstract

Objective: Timely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children. Methods: In addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013. Fifteen episodes had positive bacterial cultures and 18 had fever. The mean sCD14 values were compared in the presence or absence of fever, positive blood culture and other clinical conditions. Also, mean levels compared in different white cell counts and different four combination settings of fever and blood culture. Findings: It was statistically higher in febrile episodes, in the presence of oral mucositis, indwelling catheter infection, otitis media, and post toxic epidermal necrolysis sepsis and in instances of death within 15 days. Leukocyte count did not affect sCD14 level and in combinations of fever and blood culture, mean sCD14 values were ranked as follow: febrile culture negatives, febrile culture positives, afebrile culture positives and afebrile culture negatives. Conclusion: Although sCD14 was not sensitive in detection of bacteremia, in the absence of clinically detectable source of infection, it was significantly higher in culture positives.

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