Intravenous Lidocaine Infusion with Single Low-Dose Ketamine as an Adjuvant to General Anesthesia in Posterior Spine Fusion

How to Cite:Mostafa Mansour HusseinAhmed M ElhennawyIntravenous Lidocaine Infusion with Single Low-Dose Ketamine as an Adjuvant to General Anesthesia in Posterior Spine Fusion.J Cell Mol Anesth.7(2):e149709.https://doi.org/10.22037/jcma.v7i2.37078.

Abstract

Background: Posterior spinal fusion (PSF) is a common surgical operation used to correct degeneration of the lumbar spine with considerable postoperative pain. The primary objective of this study is to compare the total intraoperative and postoperative opioid consumption and numeric pain scale during the first 24 hours after surgery between the lidocaine/ketamine group and the narcotic-only group. Materials and Methods: Sixty adult patients (age 18?65 years) scheduled for elective PSF were included. Patients were divided randomly into either the lidocaine/ketamine group (LK group), who received lidocaine and ketamine injection in addition to usual perioperative narcotic analgesia, and the narcotic-only group (N group) who depended on narcotics only. The primary outcome measures were total intraoperative and postoperative opioid consumption and pain scores during the first 24 hours postoperatively. The secondary outcome measures were sedation score, intravenous rescue analgesia, postoperative nausea and vomiting, and pruritis during the first 24 hours postoperatively. Results: Patients in the LK group had lower intraoperative fentanyl consumption (216.3 ? 28.8 ?g) than those in the N group (363 ? 35 ?g). The LK group consumed less morphine during the first 24 hours after surgery (49.5 ? 6.0 mg) than the N group did (57.8 ? 8.6 mg). The LK group had lower pain scores at all-time intervals during the first 24 hours (2, 6, 12, and 24 hours) than the N group did. Conclusions: Intraoperative lidocaine infusion with low-dose ketamine reduced opioid consumption and pain scores in patients undergoing PSF.

Keywords

Narcotic

Ketamine

Lidocaine

Patient-controlled Analgesia

Spine Fusion

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Mostafa Mansour Hussein:[PubMed][Scholar]
Ahmed M Elhennawy:[PubMed][Scholar]