Nanoparticles of Zinc Oxide Reduces Acute Somatic Pain in Adult Female Wistar Rats

Mahnnaz  Kesmati; Mozhgan  Torabi; Maryam Ghandizadeh - Dezfuli

Zahedan Journal of Research in Medical Sciences

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Nanoparticles of Zinc Oxide Reduces Acute Somatic Pain in Adult Female Wistar Rats

Author(s):

Mahnnaz Kesmati^1,*,

Mozhgan Torabi²,

Maryam Ghandizadeh - Dezfuli³

1Department of B iology, Faculty of S cience s , Shahid Chamran University, Ahvaz, Iran

2Department of B iology, Faculty of S cience s , Shahid Chamran University, Ahvaz, Iran

3Department of B iology, Faculty of S cience s , Arak University, Arak, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 24-28

Published online:Apr 09, 2013

Article type:Research Article

Received:Nov 17, 2012

Accepted:Jan 20, 2013

How to Cite:Mahnnaz KesmatiMozhgan TorabiMaryam Ghandizadeh - DezfuliNanoparticles of Zinc Oxide Reduces Acute Somatic Pain in Adult Female Wistar Rats.Zahedan J Res Med Sci.16(2):24-28.

Abstract

Background: With appearance of nano particles as an important component in modern medicine, and considering to new properties of these components, study of their effects on human health is essential. Since zinc components influences mechanisms of nociception, the aim of this study was to evaluate the effect of nano zinc oxide as a new source of zinc and important components in pharmaceutical and hygienic cosmetic production on nociception in adult female rats.

Materials and Methods: Female rats were divided into groups: control (receiving saline 0.9%) and receiving nano ZnO (0.5, 1, and 5 mg/kg). Hot plate and tail flick tests as models of somatic acute pain were used for evaluation of the pain. The mean of latency time in paw licking and tail withdrawal respectively recorded as nociception indexes in each test for every animal. The animal numbers in each group was seven.

Results: In tail flick test, nano ZnO (0.5, 1 mg/kg) and in the hot plate test in dose of 0.5 mg/kg, induces significant analgesia (p<0.05) and with increasing of dose reduced its analgesic effect.

Conclusion: It seems nano ZnO inhibit the nociception mechanisms and these analgesic properties are more efficient in the low doses. Probably by increasing dose of nano particles aggregation phenomenon prevent of anti-nociception effects of nano ZnO.

Keywords

Pain

Nano ZnO

Female Rat

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