Comparing Poisonous Effects of Thioacetamide and Silver Nanoparticles on Enzymic Changes and Liver Tissue in Mice

Nasim  Zamani; Nooshin Naghsh; Hossain Fathpour

Zahedan Journal of Research in Medical Sciences

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Comparing Poisonous Effects of Thioacetamide and Silver Nanoparticles on Enzymic Changes and Liver Tissue in Mice

Author(s):

Nasim Zamani^1,*,

Nooshin Naghsh²,

Hossain Fathpour³

1slamic Azad University, Felavarjan Branch , Isfehan, Iran

2Department of Physiology, Faculty of Sciences, Isla mic Azad University, Felavarjan District, Isfehan, Iran

3Department of Physiology, Faculty of Basic Sciences , Islamic Azad University, Shahr-e-Kord Branch, Shahr-Korde, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 54-57

Published online:Mar 12, 2013

Article type:Research Article

Received:Jan 13, 2012

Accepted:Feb 17, 2013

How to Cite:Nasim ZamaniNooshin NaghshHossain FathpourComparing Poisonous Effects of Thioacetamide and Silver Nanoparticles on Enzymic Changes and Liver Tissue in Mice.Zahedan J Res Med Sci.16(2):54-57.

Abstract

Background: Nanoparticles are small particles which can destroy many diseases resulting from microorganisms. Due to very small size, these particles can penetrate various tissues easily like liver and many side effects. This study has compared poisonous effects of thioacetamide with silver nanoparticles on amino transferase enzymes and liver tissue in male mice.

Materials and Methods: In this study, mice were divided to four groups. First group or control was received food and water, second group received thioacetamide 50 mg/kg, third group received 3000 ppm silver nanoparticles and fourth group received a compound of silver nanoparticles 3000 ppm and thioacetamide (50 mg/kg). Then, blood from mice hearts was collected and liver tissue was separated for measuring, SGPT and SGOT enzymes, and also for tissue studies.

Results: Injection thioacetamide increased SGOT and SGPT enzymes in second group more significantly than group. However, nanosilver injection only increased SGPT enzyme significantly (p=0.02).

Conclusion: According to the results of this study, silver nanoparticles and thioacetamide can damage liver cells. But destruction of hepatocytes resulting from oxidative pressure of combination silver nanoparticles and thioacetamide was more than the other groups.

Keywords

Thioacetamide

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