Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat

Fateme  Arbabi-Kalati; Mehran Mesgari-Abbasi; Mojgan Nasirinasab; Maryam Sohrabi; Leila Roshangar; Jafar Soleimanirad; Amir A. Khaki; Yousof Doustar; Yousof Javadzade

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Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat

Author(s):

Fateme Arbabi-Kalati^1,*,

Mehran Mesgari-Abbasi²,

Mojgan Nasirinasab³,

Maryam Sohrabi⁴,

Leila Roshangar⁵,

Jafar Soleimanirad⁵,

Amir A. Khaki⁵,

Yousof Doustar⁶,

Yousof Javadzade⁷

1Department of Oral Medicine, Genetics of Non Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3Dentist, Zahedan University of Medical Sciences, Zahedan, Iran

4Department of Anatomical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran

5Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

6Department of Pathology, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

7Department of Pharmacology, Tabriz University of Medical Sciences, Tabriz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 1; e93130

Published online:Jan 17, 2011

Article type:Research Article

Received:May 05, 2010

Accepted:Jun 15, 2010

How to Cite:Fateme Arbabi-KalatiMehran Mesgari-AbbasiMojgan NasirinasabMaryam SohrabiLeila RoshangarJafar SoleimaniradAmir A. KhakiYousof DoustarYousof Javadzadeet al.Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat.Zahedan J Res Med Sci.15(1):e93130.

Abstract

Background : Cyclo-oxygenase-2 (COX-2) specific inhibitors were examined for predication or treatment of different tumors and it is indicated that COX-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. Therefore, the present study was designed in order to examine the preventive effects of a COX-2 specific inhibitor called celecoxib on 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma on rat.
Materials and Methods : In this experimental study, 30 Sprague Dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. In order to induce lingual carcinoma, 4NQO powder was prepared 3 times a week for each cage. In this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. Tongue samples were sent to laboratory for immunohistochemical (IHC) staining and histological examination.
Results : Based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib.
Conclusion : Celecoxib systematic has inhibitory effects on the 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma of tongue. The effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis.

Keywords

Chemoprevention

Cox2 Inhibitor

Oral Cancer

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