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Background:
Gabapentin is an anticonvulsant that has postoperative analgesic effects but there are limited studies on its postoperative administration.
Anesthesiology and Pain Medicine
Postoperative Gabapentin to Prevent Postoperative Pain: A Randomized Clinical Trial
Author(s):
Mahdi Panah Khahi
1, Shaqayeq Marashi1, Mohammad Reza Reza Khajavi1, Atabak Najafi1, Amirabbas Yaghooti1, Farsad Imani1,*1Department of Anesthesiology, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), [email protected], IR Iran
*Corresponding Author: Department of Anesthesiology, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), [email protected], IR Iran. Tel: +98-2166348500. Fax: +98-2144696415. Email: [email protected]
Published online:Sep 26, 2012
Article type:Research Article
Received:Mar 06, 2012
Accepted:May 08, 2012
How to Cite:Panah Khahi M, Marashi S, Khajavi MR, Najafi A, Yaghooti A, et al. Postoperative Gabapentin to Prevent Postoperative Pain: A Randomized Clinical Trial. Anesth Pain Med. 2012;2(2):. doi: https://doi.org/10.5812/aapm.4744
Abstract
Objectives:
The present study was conducted to evaluate the effect of the postoperative oral gabapentin on pain and morphine consumption.
Patients and Methods:
In a double blind, randomized study, 64 patients undergoing internal fixation of tibia under spinal anesthesia were randomly assigned to receive oral gabapentin or placebo immediately after the surgery. Pain scores were recorded at time points of 2, 12 and 24 hours postoperatively using visual analog scale (VAS). Time duration from the end of surgery until morphine administration and total morphine requirement in the first 24 hours were recorded.
Results:
The estimated duration of surgeries was 120-150 minutes. VAS score was not significantly different between the two groups at 2, 12 and 24 hours after surgery. There was no significant morphine consumption difference between the groups.
Conclusions:
Our study showed no significant analgesic efficacy of oral gabapentin 300 mg immediately after tibia internal fixation surgery under spinal anesthesia at time points of 2, 12 and 24 hours postoperatively.
Keywords
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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