Anesthesiology and Pain Medicine
Abbas Sedighinejad 1, Bahram Naderi Nabi1,*, Mohammad Haghighi1, Vali Imantalab1, Sodabe Hadadi1, Reza Erfani Sayar1, 
Ahmadreza Mirblook2Various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. We hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough.
A study had been designed to observe the effects of propofol on a fentanyl-induced cough during anesthesia induction.
We performed a randomized, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous propofol (20 mg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Group 1 patients were given fentanyl at a dosage of 4 g/kg. Group 2 received 4g/kg fentanyl and 20 mg propofol. The two groups were evaluated in 0, 5 and 10 second intervals following the injection of fentanyl.
Mean age, weight, and, height was 35 10.45, 67.99 10.92, and 165.33 31.84 respectively. The incidence of fentanyl induced cough was 29 (74.4%) in placebo group compared with 10 (25.6%) in the propofol group. There was a significant difference in the incidence and severity of cough between group 1 and 2 (P < 0.0001). This study also showed that propofol could decrease cough incidence in patients who smoke.
Priming dose of propofol (20mg) one minute prior to fentanyl injection was effective in suppressing a fentanyl-induced cough.
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Jarineshin H, Zarezadeh H, Ghazizadeh S, Mahmoudi M, Taherzadeh F, et al. Comparison of Lidocaine and Dexmedetomidine in Preventing Fentanyl-induced Cough in Patients Undergoing Elective Surgery: A Blinded Randomized Controlled Trial. Anesth Pain Med. 2025;15(6):e167186. doi: https://doi.org/10.5812/aapm-167186
Nouri N, Pournajafian A, Tahzibi S, Djalali Motlagh S. Prevention of Fentanyl Induced Cough by Ketorolac: A Prospective, Randomized, and Double-Blind Study. Anesth Pain Med. 2025;15(4):e161218. doi: https://doi.org/10.5812/aapm-161218
Hosseinzadeh Zoroofchi B, Zahedian F, Forozesfard M, Ghorbani R. Incidence of post operative nausea and vomiting following induction and maintance of general anesthesia with propofol or induction by propofol and maintenance with isoflurane: A randomized clinical trial. koomesh. 2013;15(1):e152614. doi:
Hassani V, Movassaghi G, Goodarzi V, Safari S. Comparison of Fentanyl and Fentanyl Plus Lidocaine on Attenuation of Hemodynamic Responses to Tracheal Intubation in Controlled Hypertensive Patients Undergoing General Anesthesia. Anesth Pain Med. 2013;2(3):. doi: https://doi.org/10.5812/aapm.6442
Radke OC, Sippel D, Radke K, Hilgers R, Saur P. Comparison of Two Clinical Protocols for Total Intravenous Anesthesia (TIVA) for Breast Surgery Using Propofol Combined With Either Sufentanil or Alfentanil. Anesth Pain Med. 2014;4(4):e19278. doi: https://doi.org/10.5812/aapm.19278
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