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Background:
Colonoscopy is performed without preparing sedation in many countries. However, according to the current literature patients are more satisfied when appropriate sedation is prepared for them.
Anesthesiology and Pain Medicine
Conscious Sedation and Analgesia in Colonoscopy: Ketamine/Propofol Combination has Superior Patient Satisfaction Versus Fentanyl/Propofol
Author(s):
Mohammadreza Khajavi1, Azra Emami1, 
Farhad Etezadi
1,*, Saeid Safari2, Alireza Sharifi3, Reza Shariat Moharari11Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Anesthesiology, Rasoul Akram Medical center, Iran University of Medical Sciences (IUMS), Tehran, Iran
3Department of Gastroenterology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Published online:Jun 30, 2013
Article type:Research Article
Received:Dec 14, 2012
Accepted:Feb 09, 2013
How to Cite:Khajavi M, Emami A, Etezadi F, Safari S, Sharifi A, et al. Conscious Sedation and Analgesia in Colonoscopy: Ketamine/Propofol Combination has Superior Patient Satisfaction Versus Fentanyl/Propofol. Anesth Pain Med. 2013;3(1):. doi: https://doi.org/10.5812/aapm.9653
Abstract
Objectives:
We hypothesize that propofol-ketamine may prepare more patient satisfaction compared to propofol-fentanyl combination.
Patients and Methods:
Sixty adult patients older than 18 with ASA physical status of I, II or III were enrolled in the present study after providing the informed consent. They were prospectively randomized into two equal groups: 1- Group PF: was scheduled to receive IV bolus dose of fentanyl 1g/kg and propofol 0.5mg/kg. 2- Group PK: was scheduled to receive IV bolus dose of ketamine 0.5mg/kg and propofol 0.5mg/kg. As a primary goal, patients satisfaction was assessed by the use a Likert five-item scoring system in the recovery. Comparisons of hemodynamic parameters (mean heart rate, mean systolic blood pressure, mean diastolic blood pressure), mean Spo2 values during the procedure and side effects such as nausea, vomiting, and psychological reactions during the recovery period were our secondary goals. Level of sedation during the colonoscopy was assessed with the Observers Assessment of Alertness/Sedation score (OAA/S).
Results:
Mean satisfaction scores in the group PK were significantly higher than the group PF (P = 0.005) while the level of sedation during the procedure was similar (P = 0.17). Hemodynamic parameters and SpO2 values were not significantly different (P > 0.05). Incidence of nausea and vomiting was the same in both groups.
Conclusions:
IV bolus injection of propofol-ketamine can lead to more patients satisfaction than the other protocols during colonoscopy.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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