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Anesthesiology and Pain Medicine

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https://doi.org/10.5812/aapm.9880

Intravenous Paracetamol for Postoperative Analgesia in Laparoscopic Cholecystectomy

Author(s):
Sayed Mohamadreza GoushehSayed Mohamadreza Gousheh1, Sholeh NesioonpourSholeh Nesioonpour1, Fatemeh Javaher forooshFatemeh Javaher foroosh1, Reza AkhondzadehReza Akhondzadeh1, Sayed Ali SahafiSayed Ali Sahafi1,*, Zeinab AlizadehZeinab Alizadeh1
1Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Anesthesiology and Pain Medicine:Vol. 3, issue 1; 214-8
Published online:Jun 30, 2013
Article type:Research Article
Received:Jan 05, 2013
Accepted:Feb 26, 2013
How to Cite:Gousheh SM, Nesioonpour S, Javaher foroosh F, Akhondzadeh R, Sahafi SA, et al. Intravenous Paracetamol for Postoperative Analgesia in Laparoscopic Cholecystectomy. Anesth Pain Med. 2013;3(1):. doi: https://doi.org/10.5812/aapm.9880

Abstract

Background:

Although opioids are the main choice for acute postoperative pain control, many side effects have been reported for them. NSAIDs and paracetamol have been used extensively as alternatives, and it seems that they are more effective for minor to moderate pain control postoperatively when have been used alone or in combination with opioids. As laparoscopic cholecystectomy poses moderate pain postoperatively, this study was planned to assess whether paracetamol is able to provide effective analgesia as a sole analgesic at least in the first few hours post operatively.

Objectives:

We evaluated the effect of intravenous Paracetamol on postoperative pain in patients undergoing laparoscopic cholecystectomy.

Patients and Methods:

This is a randomized double- blind clinical trial study. 30 patients ASA class I, aged 18 to 50 years, candidate for laparoscopic cholecystectomy were recruited, and randomly divided into two equal groups. Group A (paracetamol group) received 1 gr paracetamol and group B received placebo ten minutes after the induction of anesthesia. 0.1 mg/Kg Morphine was administered intravenously based on patients compliant and pain score > 3. Pain score and the opioids consumption were recorded in the first six hours postoperative. Patient\'s pain was measured by the VAS (Visual Analog Scale).

Results:

The pain score was lower in group A (P= 0.01), but the morphine consumption showed no significant difference between the groups (P= 0.24) during the first 6 hours postoperatively.

Conclusions:

Although paracetamol (1gr) has caused a better pain relief quality but it is not a suitable analgesic for moderate pain control in acute phase after surgery alone.

Keywords
Acetaminophen
Pain
Cholecystectomy
Laparoscopic
Analgesics
Opioid

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