Immunomodulatory effects of Aloe Vera on of the fungus Candida Albicans in animal model

Background: Natural products are important resources in herbal medicines and have been long used for prevention and treatment of many diseases. Aloe vera has been shown to modulate the immune response. Candidiasis is one of the most common fungal infections and Candida albicans has become the fourth most common cause of hospital infections. so in this article the effects of Aloe vera plant extracts on macrophage activation has evaluated.

Materials and Methods: First of all we infected the 5 groups of the mice with Candida Albicans and then allowed the Candida to activate in one week. Then the Aloe Vera extract (has) injected to mice. Then intraperitoneal macrophages of mice has got and in the end MTT test (has been) performed in order to evaluate the viability of intraperitoneal macrophages.

Results: In vivo results show that all of doses of the Aloe Vera extract 100mg/kg، 50، 20،10 significantly increased cell viability in presence of mitogen.

Conclusion: This study showed Aloe Vera extracts in the In vivo in presence of immune stimulator has an effective role in stimulating the immune system (in). In Further studies, processing such as isolation and purification of aloe vera components, are necessary to clarify the modulatory effects of aloe vera on macrophage function.