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Background:
Nosocomial infections increase mortality rate in neonates. Studies have attributed the use of H2 blockers as one of the various factors that increase the risk of nosocomial infections.
Archives of Pediatric Infectious Diseases
The Official Journal of Pediatric Infections Research Center, SBMU
e-ISSN 2322-1836
p-ISSN 2322-1828
Ranitidin and Nosocomial Infection in Very Low Birth Weight Infants
Authors
2Mahdieh Medical Center , Shahid Beheshti University of Medical Sciences, a_afjeh@sbmu.ac.ir, IR Iran
3Hamedan University of Medical Sciences, IR Iran
1Pediatric Infections Research Center, Shahid Beheshti University of Medical Sciences, IR Iran
*Corresponding Author: Newborn Service, Mahdieh Medical Center, Shoosh Square, Shahrezad Street, a_afjeh@sbmu.ac.ir, IR Iran. Tel: +98-2155066282. Fax: +98-2155066282. Email: a_afjeh@sbmu.ac.ir
Published online:Jul 15, 2013
Article type:Research Article
Received:Nov 08, 2012
Accepted:Nov 22, 2012
How to Cite:Afjeh SA, Sabzehei MK, Karimi A, Esmaili F. Ranitidin and Nosocomial Infection in Very Low Birth Weight Infants. Arch Pediatr Infect Dis. 2013;1(2):. doi: https://doi.org/10.5812/pedinfect.9051
Abstract
Objectives:
To define the relationship between nosocomial infection and Ranitidine in very low birth weight (VLBW) infants admitted in the NICU of a tertiary care hospital.
Patients and Methods:
All VLBW infants admitted during the study period of 3 years from April 2008 to March 2011 were included. All relevant pre-and peri-natal data including all administered medications was collected from the case notes and documented on a pre-designed questionnaire. Rate of nosocomial infection (NI) had been compared between patients who were administered Ranitidine and those who did not receive this medication.
Results:
During the study period, 564 VLBW infants were admitted in the NICU; 157, (27.8%) contracted nosocomial infections, 130 (82.8%) developed pneumonia, 21, (13.4%) had sepsis with positive blood cultures and 6 infants (1.1%) developed necrotizing enterocolitis. Factors remaining independently significant for development of NI after adjustment were as follows: RDS (P = 0.001. OR = 3.29; 95%CI = 1.646.6); CLD (P < 0.001. OR = 3.83; 95%CI = 2.067.11); anemia (P = 0.005. OR = 1.96; 95% CI = 1.23-3.13); use of Ibuprofen (P = 0.03. OR = 1.99; 95%CI = 1.06-3.74), and treatment with Ranitidine (P = 0.009, OR = 1.92, 95%CI = 1.18-3.12).
Conclusions:
Use of Ranitidine was associated with a significantly increased risk of nosocomial infections in VLBW infant.
Highlights
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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