Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Authors
Antimicrobial resistance of Staphylococcus aureus especially methicillin resistant S. aureus (MRSA) continues to be a problem for clinicians worldwide. Although difference in epidemiology and antibiotic susceptibility of methicillin resistant S. aureus (MRSA) and methicillin susceptible S. aureus (MSSA) isolates has been proposed by investigators, few data have been reported to now.
Disk diffusion method was used for determination of in vitro susceptibility of S. aureus isolates to 15 antibiotics. Susceptibility pattern of 192 non-duplicates S. aureus isolated from clinical specimens in four university hospitals in Tehran, from November 2007 to August 2008, were compared. In addition, distribution of MRSA and MSSA isolates were investigated in different specimens, on various wards, and in different age groups.
MRSA isolates were constituted 49% of all isolates. While only 1.7% of the MSSA isolates were multidrug resistant, all of MRSA were shown resistance to at least five antibiotics. Majority of isolates from patients ?65 years old were MRSA and prevalence of methicillin resistance was highest among S. aureus isolated from respiratory specimens. Also, MRSA appeared to be more prevalent in intensive care units and operation wards than in other departments.
This study has shown a relationship between methicillin resistance and resistance to other antibiotics in S. aureus isolates. Also, considerable differences were observed in epidemiology of MRSA and MSSA isolates.
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Rahimi F, Bouzari M, Katouli M, Pourshafie MR. Antibiotic Resistance Pattern of Methicillin Resistant and Methicillin Sensitive Staphylococcus aureus Isolates in Tehran, Iran. Jundishapur J Microbiol. 2013;6(2):144-149. doi: https://doi.org/10.5812/jjm.4896
Nikbakht M, Ahangarzadeh Rezaee M, Hasani A, Nahaei MR, Sadeghi J, et al. Molecular Characterization and Antimicrobial Susceptibility Patterns of Methicillin-Resistant Staphylococcus aureus Isolates in Tabriz, Northwest of Iran. Arch Pediatr Infect Dis. 2017;5(4):e61620. doi: https://doi.org/10.5812/pedinfect.61620
Fatehi Fazli SA, Fatahi-Bafghii M, Vakili M, Sadeh M. Methicillin-Resistant Staphylococcus aureus Isolated from Central Region of Iran: Antibiotic Resistance and SCCmecA Types. Jundishapur J Microbiol. 2024;17(12):e156747. doi: https://doi.org/10.5812/jjm-156747
Rahimi F, Bouzari M, Maleki Z, Rahimi F. Antibiotic Susceptibility Pattern Among Staphylococcus spp. With Emphasis on Detection of mecA gene in Methicillin Resistant Staphylococcus aureus Isolates. Arch Clin Infect Dis. 2009;4(3):. doi:
Shahkarami F, Rashki A, Rashki Ghalehnoo Z. Microbial Susceptibility and Plasmid Profiles of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible S. aureus. Jundishapur J Microbiol. 2014;7(7):e16984. doi: https://doi.org/10.5812/jjm.16984
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