The results showed a significant association between KM and QWL in all dimensions among the nursing personnel; therefore, increasing in KM can improve the QWL. Several studies confirmed this issue (
7,
14), as Dolan believed that increasing in supporting factors in workplace can improve the QWL (
15). Moreover, Cheng indicates that the KM greatly influences the organizational loyalty of hospital staff (
4). Studies that measured these two factors on nursing personnel were limited and other studies indicated that the QWL and KM can lead to productivity and high performance in hospitals (
10,
15,
16). Moreover, knowledge needs are the most important factors in QWL of the staff (
17). Based on the findings of the current study, paying special attention to the knowledge level could play a crucial role in improving QWL. Organizations that focus on the QWL, their staff have higher commitment and therefore will be more productive (
16). Hence, managers should consider KM in all staff, especially in the nursing personnel as the important treatment group. The QWL score in Ali-Asghar hospital, children and the smallest hospital, was higher than others and it was lower in Ali-ebne Abitaleb as specialty and the largest hospital. According to the one study, the QWL score was not different in teaching and non-teaching hospitals (
6). The KM score in nursing personnel, as knowledge workers, was lower in the larger hospitals than smaller hospitals (19). It seems that workload in smaller hospital is lower than larger hospitals and nursing group can allocate their time to study and to increase the knowledge. The KM process has a significant effect on operational and organizational performance appropriately (
6,
18); therefore, hospital managers should prepare workforce which motivate the personnel to rise their knowledge. Knowledge management leads to change in the characteristics of the work performed, with a view to the rapid and assertive achievement of expected results (
4). Hence, all the nursing staff could increase their productivity using KM. According to the results, younger staff had the higher KM score and it had a significant association with marital status; therefore, single staff had a higher KM score. Perhaps, there are justifying by a higher incentive in younger and single nurses. Although there was no association between KM and education level, Rocha et al. indicated that KM should increasingly be a part of the hospital organizations' strategies, as the growing valuation of knowledge can be considered unavoidable (
4). It is important for the nursing group to understand not only his/her role in knowledge management but also hospital managers, especially head nurses, should promote organizational learning by facilitating nurses as they find knowledge, share knowledge, and develop knowledge to advance the practice of nursing (
18). There were no similar studies, which were conducted in nursing personnel. It was the main limitation of the current study; thus, we had to use the near similar studies for comparison. Knowledge management is an important factor to increase productivity in organizations and improve the nurses’ QWL in hospitals. Hospital managers should pay more attention to promote KM in larger hospitals, and staff with low-education level, married and elderly. Head nurses could play a crucial role in improving QWL by institutionalization of KM in nursing group, sharing knowledge, and developing knowledge to advance the practice.