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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients
Authors
1Centre for Epidemiology and Population Health Research, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
*Corresponding Author: Campbell Aitken, Ph.D., Macfarlane Burnet Institute for Medical Research and Public Health, P.O. Box: 2284, Melbourne, Victoria 3001, Australia. Tel: +61 039 282 2114 Fax: +61 039 282 2144 Email: [email protected]
Published online:Mar 31, 2010
Article type:Research Article
Received:Nov 13, 2009
Accepted:Dec 24, 2009
How to Cite:Lewis J, Hocking J, Bowden D, Hellard M, Aitken C. Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients. Hepat Mon. 2009;9(1):. doi:
Abstract
Background and Aims: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10 and IL-17A serum levels in patients suffering from OBI.
Methods: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis B surface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA.
Results: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001).
Conclusions: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed.
Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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