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Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients
Author(s):
Masoud Asl, Kamran Lankarani, Mohammad Shahbabaie, Amir Bahrami Ahmadi, Ali Kabir, Seyed Moayed Alavian
1,*1Mamun-Al-Mahtab, M.D., F.A.C.G. Assistant Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Tel: +880 17115 67275 Fax: +880 2 882 640
*Corresponding Author: Seyed Moayed Alavian, M.D. Founder of Iran Hepatitis Network & Tehran Hepatitis Center, Professor of Internal Medicine, Gastroenterology and Hepatology, Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Grand floor of Baqiyatallah Hospital, Mollasadra Ave., Vanak Sq., P.O. Box: 14155-3651, Tehran, Iran. Tel/Fax: +98 21 8126 2072 Email: [email protected]
Published online:Mar 31, 2010
Article type:Research Article
Received:Nov 13, 2009
Accepted:Dec 24, 2009
How to Cite:Asl M, Lankarani K, Shahbabaie M, Bahrami Ahmadi A, Kabir A, et al. Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients. Hepat Mon. 2009;9(3):. doi:
Abstract
Background and Aims: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10 and IL-17A serum levels in patients suffering from OBI.
Methods: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis B surface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA.
Results: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001).
Conclusions: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed.
Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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