Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients

Guangwen Cao; Guang Cao

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Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients

Author(s):

Guangwen Cao,

Guang Cao^1,*

1Department of Epidemiology, Second Military Medical University, Shanghai, China

Hepatitis Monthly:Vol. 11, issue 2; 31-35

Published online:Mar 31, 2010

Article type:Research Article

Received:Nov 13, 2009

Accepted:Dec 24, 2009

How to Cite:Cao G, Cao G. Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients.Hepat Mon.2010;11(2):31-35.

Abstract

Background and Aims: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10 and IL-17A serum levels in patients suffering from OBI.

Methods: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis B surface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA.

Results: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001).

Conclusions: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed.

Keywords

Occult Hepatitis B Infection

Interleukin-10

Interleukin-17

HBV-DNA

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Author(s):

Guangwen Cao:[PubMed][Scholar]
Guang Cao:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients

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