Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy

Ahmad Shavakhi; Behzad Shariatifar; Shadan Chuloo; Mohammad Minakari; Mohammad Somi

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy

Author(s):

Ahmad Shavakhi^1,*,

Behzad Shariatifar²,

Shadan Akhtar Chuloo²,

Mohammad Minakari²,

Mohammad Hossein Somi³

1Al-Zahra Hospital, Isfahan University of Medical Sciences, shavakhi@med.mui.ac.ir, IR-Iran

2Isfahan University of Medical Sciences, IR-Iran

3Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, IR-Iran

Hepatitis Monthly:Vol. 8, issue 2; 121-124

Published online:Jun 30, 2008

Article type:Research Article

Received:Dec 09, 2007

Accepted:May 13, 2008

How to Cite:Shavakhi A, Shariatifar B, Chuloo S A, Minakari M, Somi M H. Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy.Hepat Mon.2008;8(2):121-124.

Abstract

Background and Aims: Ammonia has still essential role in pathogenesis of encephalopathy. It is probable that helicobacter pylori (H. pylori) infection leads to hyperammonemia and aggravates the hepatic encephalopathy via urease activity or its effect on zinc level. This study was aimed to assess the effect of H pylori eradication on hepatic encephalopathy.

Methods: In a cross-sectional study, 42 cirrhotic patients with encephalopathy were enrolled the study. For evaluation the encephalopathy, flapping tremor, number connection test (NCT) and grade of encephalopathy was determined for all of the patients. The prevalence of H pylori infection was evaluated based on positive serology by ELAISA method (Genesis Kit, UK), and/or rapid urease test (RUT) during endoscopic evaluation. One month later, after treatment, grading of encephalopathy, NCT and flapping tremor was evaluated again and data were analyzed by software SPSS.

Results: Serologic evaluation or RUT showed that 30 patients of 42 (71.42%) were positive for H pylori. In comparison between pre and post treatment, grade of encephalopathy and NCT were reduced significantly but alteration in flapping tremor was not statistically significant.

Conclusions: Our results indicate that eradication of H pylori may lead to improve the grade of hepatic encephalopathy and NCT.

Keywords

Hepatic Encephalopathy

Helicobacter Pylori

Cirrhosis

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Author(s):

Ahmad Shavakhi:[PubMed][Scholar]
Behzad Shariatifar:[PubMed][Scholar]
Shadan Chuloo:[PubMed][Scholar]
Mohammad Minakari:[PubMed][Scholar]
Mohammad Somi:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy

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