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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy
Authors
Ahmad Shavakhi1,*, Behzad Shariatifar2, Shadan Akhtar Chuloo2, Mohammad Minakari2, Mohammad Hossein Somi3
1Al-Zahra Hospital, Isfahan University of Medical Sciences, shavakhi@med.mui.ac.ir, IR-Iran
2Isfahan University of Medical Sciences, IR-Iran
3Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, IR-Iran
*Corresponding Author: Al-Zahra Hospital, Isfahan University of Medical Sciences, shavakhi@med.mui.ac.ir, IR-Iran. Tel: +98 311 7922125. Fax: +98 311 7922125. Email: shavakhi@med.mui.ac.ir
Published online:Jun 30, 2008
Article type:Research Article
Received:Dec 09, 2007
Accepted:May 13, 2008
How to Cite:Shavakhi A, Shariatifar B, Chuloo S, Minakari M, Somi M. Effect of Helicobacter Pylori Eradication on Hepatic Encephalopathy. Hepat Mon. 2008;8(2):. doi:
Abstract
Background and Aims: Ammonia has still essential role in pathogenesis of encephalopathy. It is probable that helicobacter pylori (H. pylori) infection leads to hyperammonemia and aggravates the hepatic encephalopathy via urease activity or its effect on zinc level. This study was aimed to assess the effect of H pylori eradication on hepatic encephalopathy.
Methods: In a cross-sectional study, 42 cirrhotic patients with encephalopathy were enrolled the study. For evaluation the encephalopathy, flapping tremor, number connection test (NCT) and grade of encephalopathy was determined for all of the patients. The prevalence of H pylori infection was evaluated based on positive serology by ELAISA method (Genesis Kit, UK), and/or rapid urease test (RUT) during endoscopic evaluation. One month later, after treatment, grading of encephalopathy, NCT and flapping tremor was evaluated again and data were analyzed by software SPSS.
Results: Serologic evaluation or RUT showed that 30 patients of 42 (71.42%) were positive for H pylori. In comparison between pre and post treatment, grade of encephalopathy and NCT were reduced significantly but alteration in flapping tremor was not statistically significant.
Conclusions: Our results indicate that eradication of H pylori may lead to improve the grade of hepatic encephalopathy and NCT.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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