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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Emtricitabine in Chronic Hepatitis B: A Mini Review
Authors
1Clinic of Pediatrics, Hospital of Sondrio, emipalu2003@yahoo.it, Italy
*Corresponding Author: Clinic of Pediatrics, Hospital of Sondrio, emipalu2003@yahoo.it, Italy. Tel: +39 881 685 023. Fax: +39 881 685 023. Email: emipalu2003@yahoo.it
Published online:Jun 30, 2008
Article type:Review Article
Received:Mar 01, 2008
Accepted:Jun 10, 2008
How to Cite:Palumbo E. Emtricitabine in Chronic Hepatitis B: A Mini Review. Hepat Mon. 2008;8(2):. doi:
Abstract
Emtricitabine is a cytosine nucleoside analog with antiviral activity against both hepatitis B virus (HBV) and human immunodeficiency virus (HIV). It is structurally similar to lamivudine; it differs only by a fluorine at the 5-position of the nucleic acid. This review focuses on the efficacy and tolerability of FTC in the treatment of chronic hepatitis B, both HBeAg and anti-HBe-positive. Relevant literature was identified through searches of MEDLINE (2001-January 2008). The review of literature suggests that the role of emtricitabine as monotherapy may be limited by its structural similarity to lamivudine and the corresponding risk of development of drug resistance; however, some studies seem to evidence an efficacy for emtricitabine in association with other antiviral drugs, as adefovir dipivoxil and clevudine. Other studies are needed to evaluate the efficacy of this new drug in particular in association with other antiviral drugs.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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