Full Text
Full text is available in PDF
Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
Authors
1Department of Gastroenterology and Hepatology, Medical University of Silesia, kgutski@intertele.pl, Poland
2Department of Gastroenterology and Hepatology, Medical University of Silesia, Poland
*Corresponding Author: Department of Gastroenterology and Hepatology, Medical University of Silesia, kgutski@intertele.pl, Poland. Tel: +48-327894401. Fax: +48-327894402. Email: kgutski@intertele.pl
Published online:Aug 31, 2011
Article type:Case Report
Received:May 30, 2011
Accepted:Jun 20, 2011
How to Cite:Gutkowski K, Chwist A, Hartleb M. Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature. Hepat Mon. 2011;11(8):. doi: https://doi.org/10.5812/kowsar.1735143X.713
Abstract
Corticosteroids are used widely to treat many types of disease. In general, these drugs are considered safe for the liver; however, recent reports have demonstrated that high-dose methylprednisolone (MT) may cause severe liver injury. Here, we report a case of a 24-year-old female who was given pulsed MT therapy for multiple sclerosis. MT induced icteric hepatitis and impaired liver synthetic function. Hepatotoxicity developed several weeks after drug exposure, and the causal association with MT was confirmed by unintentional rechallenge test. A brief review of the literature on corticosteroid-induced hepatotoxicity is presented.
-
Implication for health policy/practice/research/medical education:
Corticosteroid-induced liver injury may develop several weeks after short term drug exposure, therefore patients who receive corticosteroid pulses should be screened for potential liver injury. -
Please cite this paper as:
Gutkowski K, Chwist A, Hartleb M. Liver Injury Induced by High-dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature. Hepat Mon. 2011;11(8):656-61. [DOI: 10.5812/kowsar.1735143X.713]
2011 Kowsar M.P.Co. All rights reserved.
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
31
Oct
2011
Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids
Horng-Yuan Lou,
Chia-Lang Fang,
Sheng-Uei Fang,
Cheng Tiong,
Yang-Chih Cheng,
Chun-Chao Chang
Lou H, Fang C, Fang S, Tiong C, Cheng Y, et al. Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids. Hepat Mon. 2011;11(10):. doi: https://doi.org/10.5812/kowsar.1735143X.755
23
Jan
2016
Prograf Concentrations in Liver Transplantation: Correlation With Headache and Other Neurotoxic Complications?
Zahra Tolou-Ghamari,
Behnam Sanei
Tolou-Ghamari Z, Sanei B. Prograf Concentrations in Liver Transplantation: Correlation With Headache and Other Neurotoxic Complications?. Thrita J Neu. 2016;5(1):e32670. doi: https://doi.org/10.5812/thrita.32670
4
Oct
2025
Atypical Presentation of Lamotrigine Induced DRESS Syndrome: A Case Report and Review of the Literature
Ali Talebi,
Shahideh Amini,
Sepide Talebi,
Marjan Moghadamnia
Talebi A, Amini S, Talebi S, Moghadamnia M. Atypical Presentation of Lamotrigine Induced DRESS Syndrome: A Case Report and Review of the Literature. J Rep Pharm Sci. 2025;13(1):e164425. doi: https://doi.org/10.5812/jrps-164425
14
Mar
2024
Steroid-Induced Progressive Multifocal Leukoencephalopathy (PML) in HIV Patient: A Paradoxical Effect
Minoosh Shabani,
Mobin Fathy,
Hassan Pourmoshtagh,
Faezeh Maghsudloo
Shabani M, Fathy M, Pourmoshtagh H, Maghsudloo F. Steroid-Induced Progressive Multifocal Leukoencephalopathy (PML) in HIV Patient: A Paradoxical Effect. Arch Clin Infect Dis. 2024;19(2):e140933. doi: https://doi.org/10.5812/archcid-140933
5
Aug
2020
Pain Management with Acetaminophen in Patients with Liver Diseases: A Review Article
Seyed Moayed Alavian,
Zahra Parsian,
Sarvin Sanaie,
Ata Mahmoodpoor,
Hassan Soleimanpour
Alavian SM, Parsian Z, Sanaie S, Mahmoodpoor A, Soleimanpour H. Pain Management with Acetaminophen in Patients with Liver Diseases: A Review Article. Shiraz E-Med J. 2020;22(8):e106900. doi: https://doi.org/10.5812/semj.106900
More by these authors
Cited by
- Scopus by DOI: 45
Last Update: 3 weeks ago
- Scopus by Title: 45
Last Update: 3 weeks ago
- Scopus by Title (Ref): 45
Last Update: 3 weeks ago
- CrossRef: 20
Last Update: 1 hour ago
- OpenAlex: 42
Last Update: 7 hours ago
- OpenCitations: 41
Last Update: 4 days ago
Comments
Number of Comments:0