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Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids
Author(s):
1Chun-Chao Chang, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, 252, Wu-Hsing Street, Taipei, Taiwan.
*Corresponding Author: Chun-Chao Chang, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, 252, Wu-Hsing Street, Taipei, Taiwan. Tel: +886-227372181 Ext. 3903, Fax: +886-227363051, Email: [email protected]
Published online:Oct 31, 2011
Article type:Case Report
Received:Feb 24, 2011
Accepted:Aug 08, 2011
How to Cite:Lou H, Fang C, Fang S, Tiong C, Cheng Y, et al. Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids. Hepat Mon. 2011;11(10):. doi: https://doi.org/10.5812/kowsar.1735143X.755
Abstract
Background: Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare.
Objectives: We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of onychomycosis. Her condition deteriorated after withdrawal of the drug, followed solely by supportive care initially.
Case Report: Treatment with corticosteroids was started 10 days after her admission, and her condition gradually improved. Unfortunately, her condition worsened when the dosage of corticosteroids was abruptly decreased. Ultimately, her condition improved with appropriate adjustments of corticosteroid dosage.
Discussion: We conclude that corticosteroid therapy may be effective for itraconazole-induced hepatitis, especially in those patients who do not respond to conservative treatment. Notably, any decrease in the dosage should be performed with caution. We also recommend that close monitoring of liver function is mandatory during the use of itraconazole.
© 2011 Kowsar M.P.Co. All rights reserved.
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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