Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases

Behrooz Ataei; Mohammad Yazdani; Hamid Kalantari; Majid Yaran; Zary Nokhodian; Abbas Javadi; Anahita Babak; Peyman Adibi

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Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases

Author(s):

Behrooz Ataei¹,

Mohammad Reza Yazdani¹,

Hamid Kalantari¹,

Majid Yaran¹,

Zary Nokhodian¹,

Abbas Ali Javadi¹,

Anahita Babak¹,

Peyman Adibi

^2,*

1Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, IR.Iran

2Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, adibi@med.mui.ac.ir, IR.Iran

Hepatitis Monthly:Vol. 11, issue 4; 269-272

Published online:Apr 30, 2011

Article type:Research Article

Received:Mar 04, 2010

Accepted:Dec 20, 2010

How to Cite:Ataei B, Yazdani M R, Kalantari H, Yaran M, Nokhodian Z, et al. Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases.Hepat Mon.2011;11(4):269-272.

Abstract

Background: Hepatitis D virus (HDV) is dependent on hepatitis B virus (HBV) infection. Acute infection with HDV can occur simultaneously with acute HBV infection or be superimposed onto a chronic HBV infection.
Objectives: This study aimed to identify cases of HDV and determine its prevalence in patients with chronic HBV infection for the first time study in Isfahan, central Iran.
Patients and Methods: In a cross-sectional study in 2009, 346 who had been diagnosed for at least 6 months with chronic HBV were enrolled consecutively. Anti-HDV was measured by ELISA in the serum of these patients.
Results: The study included 245 males (70.8%) and 101 (29.2%) females with a mean age of 39 ± 12.4 years. Anti-HDV was present in 8 (3.5%) HBe antibody-positive patients (p = 0.36) and in 2 (2.3%) HBe antigen-positive cases (p = 0.68). No association was found between hepatitis D and probable risk factors.
Conclusions: This study demonstrates that the prevalence of HDV infection is higher in patients who are positive for HBeAb compared those who are HBeAg-positive. Therefore, most HDV antibody-positive cases in Isfahan are HBV/HDV superinfections but not coinfections.
Keywords: Hepatitis B infection; Hepatitis D infection; Prevalence

Implication for health policy/practice/research/medical education:
Chronic HDV aggregates chronic hepatitis B infection in the patients. This original paper about super and co-infection of HDV is recommended for medical practitioners and specialists in the field of infection diseases and hepatologists as well as health policy makers.
Please cite this paper as:
Ataei B, Yazdani MR, Kalantari H, Yaran M, Nokhodian Z, Javadi AA, et al. Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases. Hepat Mon. 2011;11(4):269-272.

Keywords

Hepatitis B infection

Hepatitis D infection

Prevalence

Iran

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Author(s):

Behrooz Ataei:[PubMed][Scholar]
Mohammad Yazdani:[PubMed][Scholar]
Hamid Kalantari:[PubMed][Scholar]
Majid Yaran:[PubMed][Scholar]
Zary Nokhodian:[PubMed][Scholar]
Abbas Javadi:[PubMed][Scholar]
Anahita Babak:[PubMed][Scholar]
Peyman Adibi:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases

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