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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Hedgehog Signalling Pathway: Carcinogenesis and Targeted Therapy
Authors
1Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Red Crescent Society of Islamic Republic of Iran, Tehran, Iran
*Corresponding Author: Corresponding author: Abdolali Ebrahimi, Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122432598, E-mail: Email: [email protected]
Published online:Mar 30, 2013
Article type:Review Article
Received:Apr 22, 2012
Accepted:Jul 24, 2012
How to Cite:Ebrahimi A, Larijani L, Moradi A, Ebrahimi M. Hedgehog Signalling Pathway: Carcinogenesis and Targeted Therapy. Int J Cancer Manag. 2013;6(1):e80384. doi:
Abstract
Hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. Recent research has increased our understanding of this pathway and its relation to other signalling pathways. In addition, a large number of studies confirmed the alteration of Hh signalling pathway in various types of human malignancies including basal cell carcinomas, medulloblastomas, lung, gastrointestinal, ovarian, breast, prostate cancers and leukemia. More than 50 small biomolecules have been introduced which have inhibitory effects on Hh signalling pathway. Although, in many tumors some acceptable results have been showed in phase I clinical trial, closer studies are required to improve drug bioavailability, to decrease the side effects and to find the right small molecules for specific types of cancers, considering patients overall benefits as well.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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