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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Plasma Selenium Concentration and Glutathione Peroxidase Activity in Breast Cancer Patients Before and After Chemotherapy
Authors
1Department of Nutrition, School of Health, Medical Sciences/ University of Shiraz, Iran
2Professor of surgery, Shiraz University of Medical Sciences, Iran
*Corresponding Author: Corresponding author: Masoumeh Moradi , Department of Nutrition, School of Health, Medical Sciences/ University of Shiraz, Iran, E-mail: Email: moradi_ma@yahoo.com
Published online:Sep 30, 2008
Article type:Research Article
Received:Sep 30, 2008
Accepted:Sep 30, 2008
How to Cite:Moradi M, Eftekhari M, Talei A. Plasma Selenium Concentration and Glutathione Peroxidase Activity in Breast Cancer Patients Before and After Chemotherapy. Int J Cancer Manag. 2008;1(3):e80464. doi:
Abstract
Background: The chemotherapeutic agents used for treatment of breast cancer are all shown to increase free oxygen radicals and generation of reactive oxygen species. The aim of this study was to evaluate effect of chemotherapy on plasma selenium (Se) concentration and glutathione peroxidase (GPX) activity in breast cancer patients.
Materials and Methods: Seventeen women in stage II and III breast cancer were randomly selected from their population. Plasma Se was measured with Graphite furnace atomic absorption spectroscopy and GPX activity in erythrocyte by using spectrophotometric at baseline (before chemotherapy) and after chemotherapy. normally distributed data was expressed as mean ± standard deviation. Statistical analysis was performed using Paired T-Test. Results: plasma Se concentration before and after chemotherapy was in normal range and no statistically difference was observed (156.23±25 µg/L vs. 145.23±23 µg/L respectively). After chemotherapy, there was a significant (p<0.05) higher erythrocyte GPX activity, as compared to initial activity at baseline. (22.28±4 U/grHb vs. 26.39± 4 U/grHb respectively).
Conclusion: This study indicates that sufficient Se could increase GPX activity with have a protective effect against oxidative damages.
Highlights
Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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