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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study
Authors
1Research Center for Gastrointestinal and Liver Disease, Shahid Beheshti University (MC), Taleghani Hospital, Iran
2Iran
3Associate Professor of pathology. Imam Hossein Hospital, Iran
*Corresponding Author: Corresponding author: Fatemeh Khatami, Research Center for Gastrointestinal and Liver Disease, Shahid Beheshti University (MC), Taleghani Hospital, Iran, Tel: +98-2122418872, Fax: +98-212402639, E-mail: Email: khatam81@yahoo.com
Published online:Sep 30, 2008
Article type:Research Article
Received:Sep 30, 2008
Accepted:Sep 30, 2008
How to Cite:Khatami F, Noorinayer B, Ghiasi S, Mohebi R, Hashemi M, et al. Single Nucleotide Polymorphisms of DNA Methyltransferase 1 Gene and Gastric Cancer in Iranian Patients: a Case Control Study. Int J Cancer Manag. 2008;1(3):e80455. doi:
Abstract
Background: Gastric cancer is one of the most common malignant tumors in Iran. Hypomethylation and/or hypermethylation of DNA have been described in Gastric cancer and is presumed to be an early event in this process. Objective: We hypothesized that Single nucleotide polymorphisms of DNMT1 gene may be associated with the genetic susceptibility to Gastric cancer.
Methods: 200 patients and 200 controls, both with Iranian origin were studied. Three polymorphisms were genotyped by PCR-RFLP. Allele frequencies and genotypes were compared between the cases and controls. Odds ratios were calculated and the interaction between polymorphisms, age and sex were examined.
Results: There was no significant association between DNMT1 polymorphisms and Gastric cancer.
Conclusion: We could not show any association between DNMT1 polymorphisms and gastric cancer. Larger sets of polymorphisms and sample sizes are required to test the possibility of association between polymorphisms of this gene and gastric cancer
Highlights
Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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