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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
Effect of ELF-EMF Exposure on Human Neuroblastoma Cell Line: a Proteomics Analysis
Author(s):
Hadi Hasanzadeh1, Mostafa Rezaei Tavirani2,*, Samaneh Sadat Seyyedi3, Hakimeh Zali4, Saeid Heydari Keshel4, Majid Jadidi1, Ali Abedelahi51Dept. of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran
2Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Dept. of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
4Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Dept. of Anatomy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Corresponding author: Mostafa Rezaei Tavirani, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122714248, E-mail: Email: [email protected]
Published online:Mar 31, 2014
Article type:Research Article
Received:Jun 23, 2013
Accepted:Aug 30, 2013
How to Cite:Hasanzadeh H, Rezaei Tavirani M, Seyyedi SS, Zali H, Heydari Keshel S, et al. Effect of ELF-EMF Exposure on Human Neuroblastoma Cell Line: a Proteomics Analysis. Int J Cancer Manag. 2014;7(1):e80504. doi:
Abstract
Background: Extremely low frequency electromagnetic fields (ELF-EMF) have been common in daily life all over the world. They have produced by power lines and electrical appliances, but higher levels of them have raised a lot of concerns about their carcinogenesis. Both epidemiological and laboratory studies have suggested that EMFs might increase cancer incidence, including acute childhood leukemia, brain and breast cancer.
Methods: In the present study, SH-SY5Y human neuroblastoma cell line has exposed to 2mT, 50 Hz magnetic field for 3 h. Next, effect of this exposure on protein expression including over-expression or under-expression has assessed by proteomics.
Results: Bioinformatics and statistical analysis using progenesis same spot software on the obtained 2D electrophoresis has shown that expression of 189 proteins in exposed group has changed relative to control. Besides, PCA analysis has verified results of clustering, and has shown that protein data has clustered according to experimental conditions.
Conclusion: The results of this study have shown that ELF-EMF changes cell morphology via altering protein expression, but more profound studies have needed to determine the kind of proteins altered.
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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