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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients
Author(s):
Behnoosh Tahbaz-lahaf1, MohammadEsmaeil Akbari2,*, Houshang Amir-Rassouli1, Ali Rahimipour1, Eznollah Azargashb2, Nahid Nafissi2, Farida Jahani21Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: MohammadEsmaeil Akbari, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122748001, E-mail: Email: [email protected]
Published online:Mar 31, 2014
Article type:Research Article
Received:Nov 02, 2013
Accepted:Dec 21, 2013
How to Cite:Tahbaz-lahaf B, Akbari M, Amir-Rassouli H, Rahimipour A, Azargashb E, et al. Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients. Int J Cancer Manag. 2014;7(1):e80509. doi:
Abstract
Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.
Methods: 30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.
Results: Mean GZMH value was lower in BC than healthy women (p<0.0001).
Conclusion: Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn’t effect on making positive ER, PR.
Keywords
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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