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e-ISSN 2476-468X
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Biological Pacemakers - A Review
Authors
1Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India
2Department of Cardiology, Jawaharlal Institute of Postgraduate Medicine and Research, Puducherry, India
*Corresponding Author: Corresponding author: Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India. E-mail: Email: vizhiangela@gmail.com
Published online:Jan 21, 2018
Article type:Review Article
Received:Nov 06, 2017
Accepted:Dec 10, 2017
How to Cite:Gunasekaran V, Selvaraj R. Biological Pacemakers - A Review. Int J Cardiovasc Pract. 2018;3(1):e130258. doi: https://doi.org/10.21859/ijcp-03103
Abstract
Slow heart rates, due to sinus node disease or atrioventricular conduction block, are a significant problem for many patients. Currently, these patients are treated with electronic pacemakers, which provide effective therapy, but are also associated with many problems. Use of biological pacemakers is an attractive solution to these problems. Approaches for the creation of such pacemakers include either the injection of cells that have pacemaker activity (cell-based approach) or modification of cells in the heart to induce pacemaker activity by delivering genes (gene-based approach). This article reviews the progress in the development of biological pacemakers.
Copyright
© 2018, International Journal of Cardiovascular Practice. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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