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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Assessment of Influencing Factors on Outcome of Transsphenoidal Surgery in Acromegalic Patients
Authors
Zohreh Annabestani1, Ozra TabatabaieMalazy1, Shahrzad Mohseni1, Ramin Heshmat1, Mohammad Shahrzad1, Bagher Larijani1, Mohammad-Reza Mohajeri-Tehrani
1,*
1,*1Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, IR Iran
*Corresponding Author: Corresponding author: Mohammad Reza Mohajeri Tehrani, 5th Floor, Shariati Hospital, North Kargar Avenue, Endocrinology and Metabolism Research Center, Tehran, IR Iran. Tel: +98-2188220037, Fax: +98-2188220052, E-Mail: Email: mrmohajeri@tums.ac.ir
Published online:Oct 31, 2011
Article type:Research Article
Received:Jul 05, 2011
Accepted:Aug 20, 2011
How to Cite:Annabestani Z, TabatabaieMalazy O, Mohseni S, Heshmat R, Shahrzad M, et al. Assessment of Influencing Factors on Outcome of Transsphenoidal Surgery in Acromegalic Patients. Int J Endocrinol Metab. 2011;9(4):. doi: https://doi.org/10.5812/Kowsar.1726913X.2125
Abstract
Background: Transsphenoidal surgery (TSS) is the most effective treatment for acromegalic patients, and two major factors that have been suggested as useful predictors in assessing this therapy’s success are: tumor size and preoperative basal growth hormone (GH) levels.
Objectives: The aim of this study was to illustrate the relationship between some predictor factors and transsphenoidal surgery (TSS) outcomes and its remission rate.
Patients and Methods: A total of 20 patients underwent TSS by 4 neurosurgeons in 4 university hospitals in Tehran and were followed up for 1 year. An oral glucose tolerance test was performed at 1 week after surgery and then 3, 6, and 12 months after surgery. Moreover, Insulin Growth Factor- 1 (IGF-1) was measured at 6 and 12 months after surgery.
Results: Initial remission was observed in 7 (35%) patients with a recurrence rate of 10%. The nonresponse rate was 55%. The analysis showed a significant relationship between IGF-1 and surgery outcome in the cured patients at 6 months after surgery (P = 0.005). No significant statistical relationship was found between tumor size and the TSS outcome (P = 0.696).
Conclusions: Given the high failure and recurrence rates following TSS in Iran, it seems important to pay more attention to diagnosing the disease earlier and improving surgical methods.
Copyright © 2011 Kowsar M. P. Co. All rights reserved.
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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