Circadian rhythm of acylated ghrelin, leptin, growth hormone, IGF-1, IGFBP-1 and IGFBP-3

How to Cite:Moshtaghi-Kashanian GR, Mirzaee F, khalilzadeh SH. Circadian rhythm of acylated ghrelin, leptin, growth hormone, IGF-1, IGFBP-1 and IGFBP-3. Int J Endocrinol Metab. 2011;9(4):. doi: https://doi.org/10.5812/Kowsar.1726913X.3334

Abstract

Background: Following detection of receptors for ghrelin and growth hormone (GH) in the cardiovascular system, different clinical trials have used ghrelin or GH for the treatment of cardiac patients. While some of these trials reported improvements in the patients’ situation, others reported deterioration.
Objectives: To clarify the contradictory outcomes, we designed this study to evaluate the circadian rhythms of acylated ghrelin, GH, and the related factors [Insulin-like Growth Factor-1 (IGF-1), Insulin-like Growth Factor Binding Proteins 1 and 3 (IGFBP-1 and IGFBP-3)], and leptin in patients with reduced ejection fraction (rEF).
Patients and Methods: Ten patients with rEF and an equal number of healthy control subjects matched for age and gender participated in this study according to inclusion criteria. All participants were hospitalized in the cardiac care unit (CCU), under identical conditions during collection of blood (every 2 hours). Primary processing of samples was carried out immediately and the plasma was stored at -20ºC until evaluation of the aforementioned parameters using ELISA methods.
Results: Evaluation of the collected data showed that among aged participants only circulating leptin is gender-dependent, while the patients had significantly (P < 0.001) lower ghrelin, GH, IGF-1, and IGFBP-1, but a higher level of IGFBP-3 compared to the control group. In addition, except for GH that showed a mild circadian rhythm, the parameters we examined did not have a significant circadian rhythm. Correlation analysis of the data showed a positive correlation between ghrelin and GH or IGF-1, and significant negative or positive correlations between leptin and IGFBP-1, or IGFBP-3, respectively, in both groups.
Conclusions: Here, for the first time, we show that circulating ghrelin, GH, and IGF-1 levels are reduced in the patients with rEF, and the condition of patients is deteriorated not only due to reduced IGF-1 but also due to reduction of IGFBP-1 or increase of IGFBP-3, which may be influenced by circulating leptin. Finally, disturbance of the balance between ghrelin/GH/IGF-1 and leptin may be the cause of rEF, and thus evaluation of these parameters could provide diagnostic as well as prognostic tools for the treatment of these patients.

Keywords

Ghrelin

Growth Hormone

Insulin-Like Growth Factor 1

Insulin-Like Growth Factor

Binding Protein 1

Insulin-Like Growth Factor Binding Protein 3

Leptin

Fulltext

Full text is available in PDF

Effect of Arginine Infusion on Ghrelin Secretion in Growth Hormone-Sufficient and GH-Deficient Children

Flavia Prodam,

Giulia Genoni,

Simonetta Bellone,

Silvia Longhi,

Valentina Agarla,

Gianni Bona

,et al.

5

Sep

2018

Influence of Sleep Deprivation on the 24-Hour Ghrelin Secretion Pattern

Parvin Zareian,

Seyed Reza Abtahi,

Morteza Nazari Serenjeh

30

Jun

2017

Evaluation of the Relationship Between Ghrelin Hormone Level and Some Anthropometric Variables in Women Referring to Imam Reza Hospital, Tehran, Iran

Parvin Zareian,

Mohsen Mohammadi-Far,

Fatemeh Ghasemi

14

Mar

2016

Relationship between sleep disorders and erectile dysfunction, depression and quality of life in male patients with systolic heart failure

Sharareh Zeighami Mohammadi,

Mandana Shahparian,

Habib Allah Esmaeili

20

Jul

2013

Evaluation of Left Ventricular Systolic Function after Cardiac Resynchronization Therapy in Heart Failure Patients

Zagross Hassaniani,

Jalal Kheirkhah,

Hassan Moladoust,

Hamidreza Bonakdar,

Mohammad Assadian-Rad,

Anoosh Barzigar

,et al.

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 2
Last Update: 2 hours ago
Scopus by Title: 2
Last Update: 2 hours ago
Scopus by Title (Ref): 2
Last Update: 2 hours ago
CrossRef: 2
Last Update: 10 hours ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Ghollam Reza Moshtaghi-Kashanian:[PubMed][Scholar]
Fatemeh Mirzaee:[PubMed][Scholar]
Seyyed Hossein khalilzadeh:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Circadian rhythm of acylated ghrelin, leptin, growth hormone, IGF-1, IGFBP-1 and IGFBP-3

Abstract

Fulltext

Similar Articles

Effect of Arginine Infusion on Ghrelin Secretion in Growth Hormone-Sufficient and GH-Deficient Children

Influence of Sleep Deprivation on the 24-Hour Ghrelin Secretion Pattern

Evaluation of the Relationship Between Ghrelin Hormone Level and Some Anthropometric Variables in Women Referring to Imam Reza Hospital, Tehran, Iran

Relationship between sleep disorders and erectile dysfunction, depression and quality of life in male patients with systolic heart failure

Evaluation of Left Ventricular Systolic Function after Cardiac Resynchronization Therapy in Heart Failure Patients

Crossmark

Checking

Last Update: 2 hours ago

Last Update: 2 hours ago

Last Update: 2 hours ago

Last Update: 10 hours ago