Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma

Xin  Wang; Chunyan Ma; Yajing Zhang; Lihua Ning; Hua Chen; Fang Zhou

Innovative Journal of Pediatrics

The Scientific Journal of Growth & Development Research Center

Outlines

Abstract
References
Copyright

Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma

Author(s):

Xin Wang^1,*,

Chunyan Ma²,

Yajing Zhang³,

Lihua Ning⁴,

Hua Chen⁵,

Fang Zhou⁶

Innovative Journal of Pediatrics:Vol. 23, issue 5; 525-530

Published online:Aug 13, 2013

Article type:Research Article

Received:Nov 26, 2012

Accepted:Jul 24, 2013

How to Cite:Wang X, Ma C, Zhang Y, Ning L, Chen H, et al. Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma. Inn J Pediatr. 2013;23(5):. doi:

Abstract

Objective: To determine the serum levels of eotaxin, IL-13 and total IgE (TIgE) in asthmatic children during the acute and clinical remission periods, as well as the changes in pulmonary function to determine their roles, relationships and clinical significance during asthma exacerbation. Methods: A total of 30 asthmatic children and 22 healthy children were enrolled in the study. The serum eotaxin and IL-13 levels were detected using an enzyme-linked immunosorbent assay and the TIgE level was detected using a fluorescent enzyme-linked immunosorbent assay. The asthmatic children were subjected to pulmonary function tests. Findings: The serum eotaxin, IL-13 and TIgE levels of the asthmatic children during the acute period significantly differed from those during clinical remission. The serum eotaxin, IL-13 and TIgE levels of the asthmatic children during both periods significantly differed from those of healthy children (P<0.001). The serum eotaxin levels during the acute and clinical remission periods were positively correlated with serum IL-13 and with TIgE, and serum IL-13 was correlated with serum TIgE. The pulmonary function indices of asthmatic children during the acute period significantly differed from those during clinical remission (P<0.001). The serum eotaxin and IL-13 levels in the asthmatic children were positively correlated with the forced expiratory volume in 1 second (FEV1) and the peak expiratory flow (PEF) during the acute and clinical remission periods (P<0.05). However, the serum TIgE levels in asthmatic children were not significantly correlated with the FEV1 and PEF during both periods (P>0.05). Conclusion: Serum TIgE, IL-13 and eotaxin influence each other during exacerbation of bronchial asthma and influence the corresponding pathophysiologic changes. Serum IL-13 and eotaxin could be used as markers for evaluating the severity of bronchial asthma.

Keywords

Fulltext

Click here to download PDF.

References

1.
References are available on the PDF.

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 2
Last Update: 1 month ago
Scopus by Title (Ref): 2
Last Update: 1 month ago
CrossRef: 0
Last Update: 1 hour ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Xin Wang:[PubMed][Scholar]
Chunyan Ma:[PubMed][Scholar]
Yajing Zhang:[PubMed][Scholar]
Lihua Ning:[PubMed][Scholar]
Hua Chen:[PubMed][Scholar]
Fang Zhou:[PubMed][Scholar]

The Scientific Journal of Growth & Development Research Center

Outlines

Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma

Abstract

Fulltext

References

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 hour ago