Interaction of Cisplatin with Cellular Macromolecules: A Fourier Transform Infrared Spectroscopy Study
Authors
Abstract
Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We examined the interactions of platinum with human ovarian OV 2008 cancer cells by infrared spectroscopy, through the exposure of this cell line to cisplatin. These studies showed that there was an interaction between cisplatin and DNA and proteins. Nature of these interactions and their possible effects are discussed in this paper. In summary, it has caused denaturation of proteins and modification of the interchain packing of the DNA. Our results show that infrared spectroscopy is a potentially useful technique for monitoring the interaction of elements and drugs with cell components.
Highlights
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
FTIR Biospectroscopy Investigation on Cisplatin Cytotoxicity in Three Pairs of Sensitive and Resistant Cell Line
Farhadi E, Kobarfard F, H. Shirazi F. FTIR Biospectroscopy Investigation on Cisplatin Cytotoxicity in Three Pairs of Sensitive and Resistant Cell Line. Iran J Pharm Res. 2016;15(1):e125097. doi: https://doi.org/10.22037/ijpr.2016.1775
Cisplatin Resistant Patterns in Ovarian Cell Line Using FTIR and Principle Component Analysis
Zendehdel R, Masoudi-Nejad A, Mohammadzadeh J, H. Shirazi F. Cisplatin Resistant Patterns in Ovarian Cell Line Using FTIR and Principle Component Analysis. Iran J Pharm Res. 2012;11(1):e125775. doi: https://doi.org/10.22037/ijpr.2012.1079
Predicting of Effective Dose as Biomarker for Cytotoxicity Using Partial Least Square-Fourier Transform Infrared Spectroscopy (PLS_FTIR)
Zendehdel R, Khodakarim S, H. Shirazi F. Predicting of Effective Dose as Biomarker for Cytotoxicity Using Partial Least Square-Fourier Transform Infrared Spectroscopy (PLS_FTIR). Iran J Pharm Res. 2015;14(4):e125394. doi: https://doi.org/10.22037/ijpr.2015.1729
Patterns Prediction of Chemotherapy Sensitivity in Cancer Cell lines Using FTIR Spectrum, Neural Network and Principal Components Analysis
Zendehdel R, Masoudi-Nejad A, H. Shirazi F. Patterns Prediction of Chemotherapy Sensitivity in Cancer Cell lines Using FTIR Spectrum, Neural Network and Principal Components Analysis. Iran J Pharm Res. 2012;11(2):e125852. doi: https://doi.org/10.22037/ijpr.2012.1141
Metabolome profile comparison of cisplatin sensitive and resistant in ovarian epithelial cells by magnetic resonance spectroscopy spectroscopy
Akbari Z, Awsat Mellati AL, Amanzadeh A, Nazarian A, Zamani Z, et al. Metabolome profile comparison of cisplatin sensitive and resistant in ovarian epithelial cells by magnetic resonance spectroscopy spectroscopy. koomesh. 2016;17(4):e151182. doi:
More by these authors
- Scopus by DOI: 10
Last Update: 3 weeks ago
- Scopus by Title: 10
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 9
Last Update: 6 hours ago
- OpenCitations: 0
Last Update: 4 days ago