Biotransformation of Aromatic Aldehydes by Cell Cultures of Peganum harmala L. and Silybum marianum (L.) Gaertn.

Gholamreza Asghari; Shohreh Mahmudi; Gholamali Saidfar

doi:10.22037/ijpr.2010.588

IJ Pharmaceutical Research

Home

Search Instructions

APC

Authors Guide Submit Manuscript

Outlines

Abstract
Copyright

https://doi.org/10.22037/ijpr.2010.588

Biotransformation of Aromatic Aldehydes by Cell Cultures of Peganum harmala L. and Silybum marianum (L.) Gaertn.

Author(s):

Gholamreza Asghari^1,*,

Shohreh Mahmudi²,

Gholamali Saidfar²

1Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, I. R. Iran

2Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, I. R. Iran

IJ Pharmaceutical Research:Vol. 3, issue 2; 127-130

Published online:Nov 20, 2010

Article type:Research Article

Received:Mar 01, 2004

Accepted:Aug 01, 2004

How to Cite:Asghari G, Mahmudi S, Saidfar G. Biotransformation of Aromatic Aldehydes by Cell Cultures of Peganum harmala L. and Silybum marianum (L.) Gaertn.. Iran J Pharm Res. 2022;3(2):e128194. doi: https://doi.org/10.22037/ijpr.2010.588

Abstract

Many aldehydes are important components of natural flavours. They are used in food, cosmetic, and biomedical industries in large amounts. Plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'.

Cell cultures of Silybum marianum and Peganum harmala have been studied with a view to investigat their abilities to produce flavonolignans and β-carboline alkaloids respectively. However, we have isolated S. marianum and P. harmala culture strain, which are able to metabolise several aromatic aldehydes. Ten culture strains derived from S. marianum and P. harmala were examined for their ability to biotransform exogenous aromatic aldehyde compounds, including benzaldehyde, 2-methoxybenzaldehyde, 4-methoxybenzaldehyde, cinnamaldehyde and 3-methoxy, 4-hydroxy benzaldehyde. Callus cultures of Silybum marianum and Peganum harmala were established from seedlings, and healthy suspensions were grown using the Murashige and Skoog medium. Exogenous aromatic aldehydes were fed to S. marianum and P. harmala cell suspension cultures. Biotransformation reactions were detected over 24 h of incubation. The cultures then extracted with dichloromethane and extracts subjected to GC and GC-MS analysis. The S. marianum cultured cells in this study exhibit greater selectivity in the reduction of aromatic aldehydes than P. harmala cultured cells. The ability of cultured plant cells to biotransform substrate appears to be dependent on the culture strains as well as the nature and position of the substituent on the aromatic ring.

Keywords

Comparison of Anticancer Activity of Hydroalcoholic Extracts of Curcuma longa L., Peganum harmala L., and Boswellia serrata on HeLa cells

Farzaneh Farajian Mashhadi,

Saeedeh Salimi,

Forouzan Forouzandeh,

Nooshin Naghsh

Farajian Mashhadi F, Salimi S, Forouzandeh F, Naghsh N. Comparison of Anticancer Activity of Hydroalcoholic Extracts of Curcuma longa L., Peganum harmala L., and Boswellia serrata on HeLa cells. Jundishapur J Nat Pharm Prod. 2017;12(2):e37336. doi: https://doi.org/10.5812/jjnpp.37336

8

Nov

2023

Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment

Muhammad Rizwan,

Sobia Naseem,

Arjumand Iqbal Durrani

Rizwan M, Naseem S, Durrani AI. Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment. J Adv Immunopharmacol. 2023;3(2):e138889. doi: https://doi.org/10.5812/tms-138889

19

Jun

2003

Antioxidant effect of pimpinella anisum and cinnamomum zeylanicum on cell membrane of hepatocytes, LDL, and nonenzymatic glycosylation of hemoglobin

G Naderi,

S Asgari,

M Taher,

M Gharipoor,

N Nikkhoo

Naderi G, Asgari S, Taher M, Gharipoor M, Nikkhoo N. Antioxidant effect of pimpinella anisum and cinnamomum zeylanicum on cell membrane of hepatocytes, LDL, and nonenzymatic glycosylation of hemoglobin. J Kermanshah Univ Med Sci. 2003;7(1):e81201. doi:

30

Nov

2010

THE EFFECT OF STACHYS LAVANDULIFOLIA VAHL. AND MESPILUS GERMANICA L. LEAVES HYDROALCOHOLIC EXTRACTS ON LEISHMANIA MAJOR (MRHO/IR/75/ER) IN VITRO

M Asadi,

S Bahrami,

R Ansari Samani

Asadi M, Bahrami S, Ansari Samani R. THE EFFECT OF STACHYS LAVANDULIFOLIA VAHL. AND MESPILUS GERMANICA L. LEAVES HYDROALCOHOLIC EXTRACTS ON LEISHMANIA MAJOR (MRHO/IR/75/ER) IN VITRO. Jundishapur J Nat Pharm Prod. 2010;5(1):. doi:

30

Apr

2011

The Antimycobacterium Activity of Mentha Piperita and Menthe Spicata Ethanolic Extract Against Mycobacterium Bovis in Comparison with Isoniazid

Said Maham,

Fatemeh Fallah,

Gita Eslami,

Sepideh Shamsafar,

Rahele Radmanesh,

Bita Pourkaveh

Maham S, Fallah F, Eslami G, Shamsafar S, Radmanesh R, et al. The Antimycobacterium Activity of Mentha Piperita and Menthe Spicata Ethanolic Extract Against Mycobacterium Bovis in Comparison with Isoniazid. Arch Clin Infect Dis. 2011;6(2):. doi:

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 10
Last Update: 2 weeks ago
Scopus by Title: 10
Last Update: 2 weeks ago
Scopus by Title (Ref): 0
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 1 day ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Gholamreza Asghari:[PubMed][Scholar]
Shohreh Mahmudi:[PubMed][Scholar]
Gholamali Saidfar:[PubMed][Scholar]

Outlines

Biotransformation of Aromatic Aldehydes by Cell Cultures of Peganum harmala L. and Silybum marianum (L.) Gaertn.

Abstract

Similar Articles

Comparison of Anticancer Activity of Hydroalcoholic Extracts of Curcuma longa L., Peganum harmala L., and Boswellia serrata on HeLa cells

Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment

Antioxidant effect of pimpinella anisum and cinnamomum zeylanicum on cell membrane of hepatocytes, LDL, and nonenzymatic glycosylation of hemoglobin

THE EFFECT OF STACHYS LAVANDULIFOLIA VAHL. AND MESPILUS GERMANICA L. LEAVES HYDROALCOHOLIC EXTRACTS ON LEISHMANIA MAJOR (MRHO/IR/75/ER) IN VITRO

The Antimycobacterium Activity of Mentha Piperita and Menthe Spicata Ethanolic Extract Against Mycobacterium Bovis in Comparison with Isoniazid

Crossmark

Checking

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 1 day ago