IJ Radiology
The most common ocular neoplasm in children is retinoblastoma which can spreads to the brain via the optic nerve in untreated patients. The most common treatment is enucleation, but modern eye-preserving therapies may save the globe. In advanced stages, globe-preserving strategies are often insufficient to prevent enucleation and direct infusion of chemotherapeutic agents into the ophthalmic artery may be required to control the tumor.
In this presentation, we aim to report our experience about the safety and efficacy of intra-ophthalmic artery melphalan (IAM) injection in the treatment of retinoblastoma.
Patients and Methods: Totally 46 patients were enrolled into the study. Mean age was 36.8 + 22.2 months (7100 months). Using digital subtraction angiography, under roadmap guidance a microcatheter was introduced into the ophthalmic artery, subsequently melphalan was injected over 3040 minutes. The response of the retinoblastoma tumor(s) and any associated local side effects of the treatment were observed.
Twenty-three patients were male (50%). Mean weight was 11.2 + 3.9 Kg (420) and mean height was 89.3 + 16.2 cm (65110). The disease was in the right eye in 19 patients (41.3%), left eye in 23 patients (50%) and bilateral in 3 patients (6.5%). The ophthalmic arteries were successfully cannulated except in one patient. There were not severe systemic side effects in our patients. Vasospasm happened in one patient. Canulization failed in one patient out of 29 (3.4%).
Intra-arterial melphalan injection into the ophthalmic artery is an effective and safe therapeutic modality for retinoblastoma.
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Ghassemi F, Ghanaati H, Karkhaneh R, Boujabadi L, ZiaTabatabaie S, et al. Outcome of Retinoblastoma Following Limited Sessions of Intra-Arterial Chemotherapy in Iran. I J Radiol. 2014;11(3):e16958. doi: https://doi.org/10.5812/iranjradiol.16958
Afarid M, Sadegi Sarvestani A, Rahat F, Azimi A. Intravitreal Injection of Bevacizumab: Review of our previous Experience. Iran J Pharm Res. 2018;17(3):e124799. doi: https://doi.org/10.22037/ijpr.2018.2254
Rasul Ali S, Kouhi A, Hassani S, Shakiba M, Zebardast J, et al. Vascular Blush Size Reduction, Technical Success and Safety of Intra-Arterial Embolization for Glomus Jugular Tumors: A Retrospective Cohort Study. I J Radiol. 2024;21(1):e140571. doi: https://doi.org/10.5812/ijradiol-140571
Chun HJ, Oh JS, Lee HG, Choi BG. Bronchial Artery Embolization in the Management of Hemoptysis in Patients with Hematologic Diseases: Feasibility and Short-Term Efficacy. I J Radiol. 2018;15(1):e61838. doi: https://doi.org/10.5812/iranjradiol.61838
Aoude A, Ghanaati H, Faghih Jouibari M, Shakiba M, Khaleghi M, et al. Embolization of Intracranial Arteriovenous Malformations Using Onyx in 53 Patients. I J Radiol. 2017;14(3):e37696. doi: https://doi.org/10.5812/iranjradiol.37696
Checking
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
