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International Cardiovascular Research Journal
An annual journal in scientific affiliation with the Cardiovascular Research Center, Shiraz University of Medical Sciences
e-ISSN 2251-9149
p-ISSN 2251-9130
Image Credit:Int Cardiovasc Res J
Outline
Comparison of Continuous and Non-Continuous Aerobic Exercise on Serum Vascular Endothelial Growth Factor and Endostatin in Rats with Coronary Artery Disease
Authors
1Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish, IR Iran
2Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, IR Iran
3Department of Sport Physiology, University of Tehran, Tehran, IR Iran
4Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, IR Iran
*Corresponding Author: Reza Nouri, Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran, Tel: +98-9138122729, E-mail: nuri_r7@ut.ac.ir. Email: nuri_r7@ut.ac.ir
Published online:Jun 15, 2020
Article type:Research Article
Received:Jan 22, 2020
Accepted:May 31, 2020
How to Cite:Dehghan E, Nouri R, Ravasi AA, Nekooei M. Comparison of Continuous and Non-Continuous Aerobic Exercise on Serum Vascular Endothelial Growth Factor and Endostatin in Rats with Coronary Artery Disease. Int Cardiovasc Res J. 2020;14(2):e101280. doi:
Abstract
Background:
Physical activities are associated with a decreased risk of Coronary Heart Disease (CHD), which is one of the widespread Cardiovascular Diseases (CVDs).
Objectives: The present study aimed to compare the effects of continuous and non-continuous aerobic exercises on serum Vascular Endothelial Growth Factor (VEGF) and Endostatin (ES) in rats with coronary artery disease.
Methods: In this study, 40 healthy male Wistar rats (age: two months, weight: 200 - 250 g) were divided into continuous and non-continuous aerobic exercises with Myocardial Infarction (MI), control, and sham groups. After treatment of the rats by Isoproterenol (ISO), the experimental groups underwent continuous and non-continuous aerobic exercises on a treadmill for eight weeks. The means of the variables were compared using ANOVA. Moreover, Scheffe’s post hoc test was used to clarify the exact zones of differences in the SPSS 21 software (P ≤ 0.05).
Results: The results demonstrated that both continuous and non-continuous aerobic exercises increased VEGF in comparison to the control group (P = 0.001). However, no significant difference was observed between the experimental groups and the control group with respect to ES (P = 0.09).
Conclusion: Continuous and non-continuous aerobic exercises could increase angiogenesis in coronary artery disease. Moreover, both methods might have the same positive effect on rehabilitation of patients with MI. Therefore, such exercises could be used as a complementary treatment alongside medications for MI patients.
Highlights
References
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Copyright
© 2020, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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