A Study on Hs-CRP, Carotid Intima Media Thickness, and Lipid Profile in Children of Patients with Premature CAD

Usha  Dudeja Bindal; Santosh  Kumar Gupta; Vivek  Bindal; Mridul Kumar  Daga; Gaurav  Pradhan

doi:10.17795/icrj-9(4)193

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Home

Instructions

APC

Authors Guide Submit Manuscript

https://doi.org/10.17795/icrj-9(4)193

A Study on Hs-CRP, Carotid Intima Media Thickness, and Lipid Profile in Children of Patients with Premature CAD

Author(s):

Usha Dudeja Bindal^1,*,

Santosh Kumar Gupta²,

Vivek Bindal³,

Mridul Kumar Daga⁴,

Gaurav Pradhan⁵

1Department of Biochemistry, Dr. BS Ambedkar Medical College, New Delhi, India

2Department of Biochemistry, Maulana Azad Medical College, New Delhi, India

3Ganga Ram Institute of Post Graduate Medical Education and Research, New Delhi, India

4Department of Medicine, Maulana Azad Medical College, New Delhi, India

5Department of of Radiodiagnosis, Maulana Azad Medical College, New Delhi, India

International Cardiovascular Research Journal:Vol. 9, issue 4; e10871

Published online:Dec 31, 2015

Article type:Research Article

Received:Aug 15, 2014

Accepted:Jun 14, 2015

How to Cite:Dudeja Bindal U, Kumar Gupta S, Bindal V, Daga MK, Pradhan G. A Study on Hs-CRP, Carotid Intima Media Thickness, and Lipid Profile in Children of Patients with Premature CAD. Int Cardiovasc Res J. 2015;9(4):e10871. doi: https://doi.org/10.17795/icrj-9(4)193

Abstract

Background: This study aimed to evaluate the risk markers of Coronary Artery Disease (CAD), so that appropriate lifestyle changes can be instituted early to prevent or delay development of the disease.
Objectives: This study aimed to evaluate the risk markers of CAD based on inflammation and arterial morphology; i.e., high sensitivity C-Reactive Protein (hs-CRP) and carotid artery Intima Media Thickness (IMT), in children of patients with premature CAD.
Patients and Methods: This was a case-control study with predetermined end points. It was conducted on 40 subjects randomly selected from the children of premature CAD patients and 40 age- and sex-matched healthy controls. Blood levels of hs-CRP, lipid profile, and carotid IMT were assessed for all the subjects. The relationship among these parameters was evaluated by univariate and multivariate analyses using the SPSS statistical software, version 22.0 and P < 0.05 was considered as statistically significant.
Results: The mean values of Total Cholesterol (TC, 139.8 ± 24 vs. 111.3 ± 14.7, P < 0.05), Triglycerides (TG, 81.8 ± 15.3 vs. 63.4 ± 10.8, P < 0.05), Low Density Lipoprotein (LDL, 85.2 ± 22.2 vs. 57.5 ± 14.1, P < 0.05), hs-CRP (1.2 ± 0.77 vs. 0.79 ± 0.27, P < 0.05) and carotid artery IMT (0.49 ± 0.09 vs. 0.422 ± 0.03, P < 0.05) were significantly higher in the cases compared to the controls. Also, both LDL/High Density Lipoprotein (HDL) and TC/HDL ratios were significantly higher in the cases compared to the controls. Moreover, a significant positive correlation was found between carotid IMT and hs-CRP.
Conclusions: Children of patients with premature CAD showed a significantly higher incidence of dyslipidemia as well as significantly increased levels of the inflammation marker, hs- CRP, compared to the age- and sex-matched controls. This indicates that atherosclerosis is not only a disease of lipid deposition, but also an inflammatory process. This was further confirmed by demonstration of a significantly raised IMT.

Keywords

Atherogenesis

Cystatin-C

Carotid Intima-Media Thickness

Fulltext

The full text is available in PDF.

References

1.
The references are available in PDF.

Correlation of premature coronary artery disease in parents with dyslipidemia in their children

M Masoumi,

Z Jalili,

F Sabzi,

B moradi,

G Abdoli,

F Siah

,et al.

Masoumi M, Jalili Z, Sabzi F, moradi B, Abdoli G, et al. Correlation of premature coronary artery disease in parents with dyslipidemia in their children. J Kermanshah Univ Med Sci. 2003;7(2):e81210. doi:

15

Jul

2019

A Prospective Study of Prevalence of Carotid Artery Disease in Patients with Coronary Artery Disease and its Correlation with Traditional Atherosclerotic Risk Factors in Central India

Umesh Kumar Chandra,

Yashwant Panwar,

Anil Bharani

Chandra UK, Panwar Y, Bharani A. A Prospective Study of Prevalence of Carotid Artery Disease in Patients with Coronary Artery Disease and its Correlation with Traditional Atherosclerotic Risk Factors in Central India. Int J Cardiovasc Pract. 2019;4(2):e130549. doi: https://doi.org/10.29252/ijcp-24576

18

Apr

2015

Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus

Murat Ersoy,

Hatice Nilgun Selcuk Duru,

Murat Elevli,

Ozlem Ersoy,

Mahmut Civilibal

Ersoy M, Selcuk Duru HN, Elevli M, Ersoy O, Civilibal M. Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus. Inn J Pediatr. 2015;25(2):-. doi: https://doi.org/10.5812/ijp.368

30

Jun

2009

C-Reactive Protein in Angiographically Documented Stable Coronary Disease

Mohammad Javad Zibaeenezhad,

P Ghanbari,

B Shahryari,

Kamran Aghasadeghi

Zibaeenezhad MJ, Ghanbari P, Shahryari B, Aghasadeghi K. C-Reactive Protein in Angiographically Documented Stable Coronary Disease. Int Cardiovasc Res J. 2009;3(2):e68466. doi:

19

Jun

2019

Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children

Ju-Hyung Lee,

Sun Hwa Lee,

Keun Sang Kwon,

Chan Uhng Joo,

Dae-Yeol Lee,

Min Sun Kim

Lee J, Lee SH, Kwon KS, Joo CU, Lee D, et al. Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children. Inn J Pediatr. 2019;29(3):e86114. doi: https://doi.org/10.5812/ijp.86114

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 1
Last Update: 1 month ago
Scopus by Title: 1
Last Update: 1 month ago
Scopus by Title (Ref): 1
Last Update: 1 month ago
CrossRef: 1
Last Update: 1 day ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Usha Dudeja Bindal:[PubMed][Scholar]
Santosh Kumar Gupta:[PubMed][Scholar]
Vivek Bindal:[PubMed][Scholar]
Mridul Kumar Daga:[PubMed][Scholar]
Gaurav Pradhan:[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Outlines

A Study on Hs-CRP, Carotid Intima Media Thickness, and Lipid Profile in Children of Patients with Premature CAD

Abstract

Fulltext

References

Similar Articles

Correlation of premature coronary artery disease in parents with dyslipidemia in their children

A Prospective Study of Prevalence of Carotid Artery Disease in Patients with Coronary Artery Disease and its Correlation with Traditional Atherosclerotic Risk Factors in Central India

Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus

C-Reactive Protein in Angiographically Documented Stable Coronary Disease

Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children

Crossmark

Checking

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 day ago