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International Cardiovascular Research Journal
The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences
Outlines
QT Dispersion after Thrombolytic Therapy
Author(s):
Saeed Oni Heris1, Behzad Rahimi2, Gholamreza Farid aalaee3,*, Mojgan Hajahmadi2, Hojjat Sayyadi4, Bahman Naghipour51Shahid Rajaee Heart Center, Tehran, Iran
2Cardiology Department, Urmia University of Medical Sciences, Urmia, Iran
3Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran
4Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Department of Anesthesiology, Madani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Corresponding author: Gholamreza Farid aalaee, Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran Email: [email protected]
Published online:Dec 01, 2014
Article type:Research Article
Received:Apr 19, 2017
Accepted:Jul 16, 2014
How to Cite: Oni Heris S, Rahimi B, Farid aalaee G, Hajahmadi M, Sayyadi H, et al. QT Dispersion after Thrombolytic Therapy. Int Cardiovasc Res J. 2017;8(4):e11681. doi:
Abstract
Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).
Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.
Patients and Methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one–way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.
Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).
Conclusions: : Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.
References
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Copyright
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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