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International Cardiovascular Research Journal
The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences
Outlines
The Association of Serum Lactate Dehydrogenase Levels with In- Hospital Mortality due to Pulmonary Embolism
Author(s):
Samad Ghaffari
1, Reza Hajizadeh2, Tooba Mohammadi3, Hadiseh Kavandi1, Kamran Mohammadi1, Mehdi Mohebbalizadeh3, Sahar Ghodratizadeh4, Amin Sedokani2, 3,*1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
2Department of Cardiology, Urmia University of Medical Sciences, Urmia, IR Iran
3Student Research Committee, Urmia University of Medical Sciences, Urmia, IR Iran
4Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, IR Iran
*Corresponding Author: Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran. Tel: +98-4432372917, Email: [email protected].[email protected]
Published online:Sep 30, 2022
Article type:Research Article
Received:Nov 30, 2021
Accepted:Sep 10, 2022
How to Cite:Ghaffari S, Hajizadeh R, Mohammadi T, Kavandi H, Mohammadi K, et al. The Association of Serum Lactate Dehydrogenase Levels with In- Hospital Mortality due to Pulmonary Embolism. Int Cardiovasc Res J. 2022;16(3):e121597. doi:
Abstract
Background: A significant correlation exists between elevated lactate dehydrogenase (LDH) levels and thrombotic events, yet the prognostic value of this biomarker in patients with pulmonary embolism (PE) remains elusive. Finding new biomarkers can help us achieve better risk stratification and treatment strategies to reduce the mortality of PE patients.
Objectives: We aimed to determine the possible association between serum LDH and the in-hospital mortality of PE patients.
Methods: In this cross-sectional study, 217 patients with PE (diagnosed by computed tomography angiography) and a serum LDH level documented within the first 24 hours of admission were included. Our exclusion criteria were hepatic and renal diseases, pregnancy, hemolytic disorders, left ventricular infarction, recent stroke, positive history of active cancer, acute and chronic infections, and reticuloendothelial-related diseases.
Results: The mean age of patients was 63.04 ± 16.81 years; 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that LDH and white blood cells (WBC) were independent predictors of in-hospital mortality; however, this association was insignificant. Univariate analysis showed that higher levels of LDH, WBC, and red cell distribution width (RDW) had a significant association with in-hospital mortality (P < 0.05). The receiver operating characteristics curve showed that an LDH cut-off value of 515 U/l had a sensitivity of 91.3% and specificity of 45.9% in predicting in-hospital mortality (95% CI = 0.636 – 0.761, P = 0.0003).
Conclusion: LDH can be an excellent prognostic marker for predicting in-hospital death in patients with pulmonary embolism.
References
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Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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