Investigation of the Possible Risk Factors Associated with Subclinical Left Ventricular Dysfunction Assessed by 2D Speckle Tracking Echocardiography in Patients with Type 2 Diabetes Mellitus and Normal Ejection Fraction

Mehdi Pishgahi; Fariba Bayat; Rama Bozorgmehr; Shirin Ghane Fard; Hamid Rafiei Sadr; Seyedeh Maryam Motahari; Kimia Karimi Toudeshki

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Investigation of the Possible Risk Factors Associated with Subclinical Left Ventricular Dysfunction Assessed by 2D Speckle Tracking Echocardiography in Patients with Type 2 Diabetes Mellitus and Normal Ejection Fraction

Author(s):

Mehdi Pishgahi

¹,

Fariba Bayat²,

Rama Bozorgmehr

³,

Shirin Ghane Fard⁴,

Hamid Rafiei Sadr³,

Seyedeh Maryam Motahari³,

Kimia Karimi Toudeshki

^1,*

1Cardiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

2Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

3Internal Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

4Pediatric Endocrinologist, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

International Cardiovascular Research Journal:Vol. 17, issue 2; e138792

Published online:Jun 30, 2023

Article type:Research Article

How to Cite:Pishgahi M, Bayat F, Bozorgmehr R, Ghane Fard S, Rafiei Sadr H, et al. Investigation of the Possible Risk Factors Associated with Subclinical Left Ventricular Dysfunction Assessed by 2D Speckle Tracking Echocardiography in Patients with Type 2 Diabetes Mellitus and Normal Ejection Fraction. Int Cardiovasc Res J. 2023;17(2):e138792. doi:

Abstract

Background: Subclinical left ventricular dysfunction is an important predictor of cardiovascular death, detected via the global longitudinal strain (GLS) echocardiographic parameter. While T2DM is associated with a worse GLS, it is not cost-effective to perform 2D speckle tracking echocardiography for all asymptomatic T2DM patients to screen for early signs of subclinical left ventricular dysfunction.

Objectives: We aimed to investigate the association of possible risk factors with subclinical left ventricular dysfunction assessed by 2D speckle tracking echocardiography in T2DM patients with normal ejection fraction, excluding patients with comorbidities associated with left ventricular dysfunction such as hypertension or any cardiovascular disease.

Methods: This cross-sectional study involved patients aged >18 with type 2 diabetes mellitus (T2DM) and EF ≥ 50% referred to Shohada-e-Tajrish Hospital, Tehran, Iran, from May 2, 2023, to June 21, 2023. Patients with any history or signs and symptoms of heart disease and hypertension were excluded. The correlation of GLS with age, BMI, duration of diabetes, systolic (SBP) and diastolic blood pressure (DBP), and laboratory parameters was assessed using Pearson's correlation test, with P < 0.05 denoting significance.

Results: In this cross-sectional study, 118 patients consisting of 70 women (59.32%) and 48 men (40.68%) with T2DM were enrolled. The mean age of the participants was 49.61 ± 5.10 years. The mean GLS was -16.71 ± 2.14%. The GLS correlated positively with BMI (P = 0.038 and r = 0.197), SBP (P = 0.003 and r = 0.268), DBP (P = 0.023 and r = 0.209), homocysteine (P = 0.001 and r = 0.310), HbA1C (P = 0.046 and r = 0.184), LDL (P = 0.034 and r = 0.203), and TG (P < 0.001 and r = 0.375), and negatively with GFR (P < 0.001 and r = -0.363).

Conclusions: BMI, SBP, DBP, homocysteine, HbA1C, LDL, TG, and GFR correlated with subclinical left ventricular dysfunction assessed by GLS in patients with T2DM; these markers may offer value in selecting T2DM patients for cost-effective 2D speckle tracking echocardiography screening of subclinical left ventricular dysfunction.

Keywords

Echocardiography, Diabetes Mellitus, Global Longitudinal Strain, GLS, Ventricular Dysfunction

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Left Ventricular Strain in Patients with Hypertensive Heart Disease and Normal Ejection Fraction Assessed by Speckle Tracking Echocardiography

Hamideh Khesali,

Sara Barzegar,

Raheleh Kaviani,

Amir Askarinejad,

Hamed Bazrafshan Drissi,

Mohamad Ali Ghaznavi

Khesali H, Barzegar S, Kaviani R, Askarinejad A, Bazrafshan Drissi H, et al. Left Ventricular Strain in Patients with Hypertensive Heart Disease and Normal Ejection Fraction Assessed by Speckle Tracking Echocardiography. Int Cardiovasc Res J. 2022;16(4):e130653. doi:

1

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Echocardiographic Data and B-Type Natriuretic Peptide in Children and Adolescents with Type I Diabetes Mellitus and Normal Ejection Fractio

Mohammadreza Edraki,

Rafat Noiaghdam,

Hossein Moravej,

Hamid Amoozgar

Edraki M, Noiaghdam R, Moravej H, Amoozgar H. Echocardiographic Data and B-Type Natriuretic Peptide in Children and Adolescents with Type I Diabetes Mellitus and Normal Ejection Fractio. Int Cardiovasc Res J. 2019;13(4):e83032. doi:

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Nahid Kianmehr,

Marjan Hajahmadi,

Pegah Joghataie,

Niloofar Amirinasab Sarabi

Pazoki M, Kianmehr N, Hajahmadi M, Joghataie P, Amirinasab Sarabi N. Early Detection of Subclinical Left Ventricular Dysfunction in Patients with Systemic Lupus Erythematosus: A Case-Control Study. Jundishapur J Chronic Dis Care. 2022;11(2):e121401. doi: https://doi.org/10.5812/jjcdc.121401

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Apr

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Assessment of Correlation of Left Ventricular Diastolic Functional Indices Between Gated Myocardial Perfusion SPECT and Echocardiography

Lida Peivandi,

Vahid Reza Dabbagh Kakhki

Peivandi L, Dabbagh Kakhki VR. Assessment of Correlation of Left Ventricular Diastolic Functional Indices Between Gated Myocardial Perfusion SPECT and Echocardiography. I J Radiol. 2017;14(Special Issue):e48002. doi: https://doi.org/10.5812/iranjradiol.48002

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Prevalence of diastolic dysfunction in patient with heart failure symptoms

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Author(s):

Mehdi Pishgahi:[PubMed][Scholar]
Fariba Bayat:[PubMed][Scholar]
Rama Bozorgmehr:[PubMed][Scholar]
Shirin Ghane Fard:[PubMed][Scholar]
Hamid Rafiei Sadr:[PubMed][Scholar]
Seyedeh Maryam Motahari:[PubMed][Scholar]
Kimia Karimi Toudeshki:[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Investigation of the Possible Risk Factors Associated with Subclinical Left Ventricular Dysfunction Assessed by 2D Speckle Tracking Echocardiography in Patients with Type 2 Diabetes Mellitus and Normal Ejection Fraction

Abstract

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