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Journal of Cellular & Molecular Anesthesia

e-ISSN 2476-5120
p-ISSN 2538-2462
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Cover image of the article: Dexmedetomidine Mechanism of Action: an update

Image Credit:J Cell Mol Anesth

Outline

https://doi.org/10.22037/jcma.v1i2.11398

Dexmedetomidine Mechanism of Action: an update

Authors

Sara SalarianSara Salarian ORCID1,*, Bahar Taherkhanchi2, Ali DabbaghAli Dabbagh ORCID1, Mahboubeh Darban3, Bahador BagheriBahador Bagheri ORCID4
1Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Pediatric, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran
4Cancer Research Center and Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran
*Corresponding Author: Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Email: sarasalarian@yahoo.com
Journal of Cellular & Molecular Anesthesia:Vol. 1, issue 2; e149509
Published online:Mar 16, 2016
Article type:Review
How to Cite:Salarian S, Taherkhanchi B, Dabbagh A, Darban M, Bagheri B. Dexmedetomidine Mechanism of Action: an update. J Cell Mol Anesth. 2016;1(2):e149509. doi: https://doi.org/10.22037/jcma.v1i2.11398

Abstract

Dexmedetomidine (PRECEDEX) is an imidazole derivative that is a highly selective a2 receptor agonist. Activation of the a2 adrenergic receptors by dexmedetomidine leads to both sedation and analgesia; with negligible respiratory and cardiovascular side effects. The drug is likely to be increasingly used for sedation and as an anesthetic adjunct.

Highlights

KeywordsDexmedetomidineneuroprotectionreperfusion injury

References

  • 1.
    References are in the PDF file of the article.

Copyright

© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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