Histopathologic Changes and Cellular Events of Organs Systems in COVID-19

Background: Understand more about histopathological events of COVID-19 helps to choose more proper management strategies and treatments. There are several ways to histopathologic evaluations; including, tissue sampling of different organs in living people as biopsies or search for these data in tissues of dead people as autopsies or necropsies, that in this comprehensive review we tried to evaluate histopathologic concordance between findings of various tissue samplings of different sites which may work as a mirror of each other especially mucocutaneous findings may indicative of similar events of other parts. Method: Based on main key words, we searched databases of PubMed, Scopus, Google Scholar, Medscape and CEBD coronavirus dermatology resource of Nottingham University and included the most relevant and well-designed studies with higher level of evidences and higher sample size. Result: In this study, selected pathological samples from different tissues including skin and mucosa, lungs, gastrointestinal tract and kidneys were studied and summarized in patients with COVID-19. Pathological findings in these patients were included by organ and listed in order of prevalence. Conclusion: Tissue sampling in patients with COVID-19 may be helpful in understanding the pathophysiology of the disease as much as possible. Although most of these samples are taken after patients die, sampling before the more advanced stages of the disease could also show signs of tissue involvement before full systemic symptoms appear. ?