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Journal of Clinical Research in Paramedical Sciences
The Official Journal of Paramedical School, KUMS
e-ISSN 2345-3338
p-ISSN 2322-1593
Image Credit:J Clin Res Paramed Sci
Outline
Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals
Authors
Amir Peymani1, Moein Yeylagh Beigi2, Mahdi Mohammadi Ghanbarlou2, Reza Najafipour1, Rasoul Samimi 3,*
1Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
2Department of Medical Microbiology, Qazvin University of Medical Sciences, Qazvin, Iran
3Department of Internal Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
*Corresponding Author: Corresponding author: Rasoul Samimi , Department of Internal Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran, E-mail: Email: samimi.rasoul@gmail.com
Published online:May 14, 2014
Article type:Research Article
Received:Oct 10, 2013
Accepted:Mar 19, 2014
How to Cite:Peymani A, Yeylagh Beigi M, Mohammadi Ghanbarlou M, Najafipour R, Samimi R. Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals. J Clin Res Paramed Sci. 2014;3(1):e82084. doi:
Abstract
Introduction: Pseudomonas aeruginosa and Enterobacter cloacae are the most common organisms involved in clinical disease among patients admitted in ICUs. The treatment of these infections is often difficult due to several virulence factors and drug resistance
mechanisms. The aim of this study was to evaluate multidrugresistance pattern among clinical P. aeruginosa and E. cloacae isolates collected from ICUs.
Methods: In total, 82 and 49 P. aeruginosa and E. cloacae isolates were collected from ICUs of Tehran and Qazvin hospitals. The species identification was performed by standard laboratory methods. Antimicrobial susceptibility and multidrug resistance (MDR) pattern
were further evaluated by Kirby-Baure method according to CLSI guideline.
Results: In this study, the highest resistance rate was shown to cefpodoxime (98.8%) and cefotaxime (97.6%) in P. aeruginosa and to amoxicillin-clavulanic (98%) acid and ampicillin (95.9%) in E. cloacae isolates. Twenty six (53.1%) E. cloacae and 43 (52.4%) P. aeruginosa isolates showed the multidrug resistance pattern.
Conclusion: The present study showed the considerable frequency of MDR pattern among P. aeruginosa and E. cloacae isolates collected from studied hospitals. Therefore, there is need for efficient infection control and appropriate therapeutic practices, especially in ICUs.
Highlights
References
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Copyright
© 2014, Journal of Clinical Research in Paramedical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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