Effects of injective Lidocaine in reduction of complications due to diazepam injection

¯Abstract Background: Pain of Injection and thrombophlebitis are of complications of diazepam injection which is used in induction of anesthesia. Objective: This study was designed to evaluate the effect of using lidocaine as a preinjection in reduction of complications due to diazepam. Methods: 116 Patients were evaluated in a randomized double blind study in university hospitals of Kerman in 2000. The patients who had no problems in their upper extrimities and were classified as class I and II of ASA classification received 0.2 mg/kg of diazepam as two separate sample one minute after receiving 0.5 mg/kg of lidocaine (1%) and it’s equal volume of Nacl (0.9%). Injections were done in veins of hands in left and right upper extremities. The pain of injection was recorded by another researcher as a likert scale. The third researcher checked the patients for phlebitis after 24 hours. Findings: 104 of the samples reported pain of injection after Nacl receiving and this rate for lidocaine was 16(p< 0.001). The severity of pain was different between two groups and lidocaine group had less score(p<0.0001). Also the rate of phlebitis during first 24 hours was less (8 for case and 18 for control group) in lidocaine groups(p< 0.01). Conclusion: Although we didn’t understand the exact mechanism of lidocaine in reduction of complications of intravenous diazepam administration but it` s positive effect which is reported in some other reports makes it a good choice to have anesthesia with less complications.