Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects
Authors
Abstract
Background: Vitamin D receptor (VDR) gene polymorphisms cause functional differences in immunomodulatory action of vitamin D. An association between VDR gene BSMI polymorphisms and systemic lupus erythematosus (SLE) has been documented. Objective: To compare the VDR gene BSMI polymorphisms in patients with SLE and healthy controls. Methods: This was a case-control study conducted in the city of Mashhad (Iran). Sixty patients with lupus from two outpatient rheumatology clinics and 45 non-relative healthy controls of the same sex were selected using the census procedure. VDR gene typing was performed based on polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The results were analyzed using chi square test while a p<0.05 was considered as significant. Findings: The distribution of VDR genotyping of BSMI polymorphisms in patients with SLE were 23.3% for BB, 60% for Bb and 16.7% for bb. Similarly, the values found for healthy group were 33.3%, 46.7%, and 20% for BB, Bb, and bb, respectively. There was no statistically significant difference between two groups. Conclusion: No significant difference in relative frequency of VDR gene BSMI polymorphisms in SLE patients and healthy individuals was established.
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
Association Study of the PTPN22 Gene Polymorphisms with Systemic Lupus Erythematosus in Lorestan Province of Iran
Shahrokhi SZ, Kazemi Nezhad SR, Baharvand Ahmadi S, Akhoond MR. Association Study of the PTPN22 Gene Polymorphisms with Systemic Lupus Erythematosus in Lorestan Province of Iran. Gene Cell Tissue. 2017;4(3):e12023. doi: https://doi.org/10.5812/gct.12023
Programmed Cell Death 1 Gene Polymorphism as a Risk Factor for Systemic Lupus Erythematosus in Northwest Iran
Nasiri P, Zeinalzadeh N, Gozali P, Ardalan MR, Haghi M. Programmed Cell Death 1 Gene Polymorphism as a Risk Factor for Systemic Lupus Erythematosus in Northwest Iran. J Inflamm Dis. 2023;27(3):e153344. doi: https://doi.org/10.69107/jid-153344
Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran
Mohammadoo-Khorasani M, Salimi S, Tabatabai E, Sandoughi M, Zakeri Z. Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran. Zahedan J Res Med Sci. 2013;16(12):e23400. doi:
Association between VDR Gene Polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population
Hashemi SM, Arbabi N, Hashemi M, Mashhadi MA, Allahyari A, et al. Association between VDR Gene Polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population. Int J Cancer Manag. 2017;10(3):e8807. doi: https://doi.org/10.5812/ijcm.8807
Gene Variants of Vitamin D Receptor (TaqI T > C (rs731236) and BsmI G > A (rs1544410) in Urolithiasis
Seyedzadeh A, Rahimi Z, Tohidi MR, Soraya N. Gene Variants of Vitamin D Receptor (TaqI T > C (rs731236) and BsmI G > A (rs1544410) in Urolithiasis. J Kermanshah Univ Med Sci. 2024;28(2):e143931. doi: https://doi.org/10.5812/jkums-143931
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 5 days ago