Comparison of fasting glucose and oral glucose tolerance tests in diagnosis of diabetes mellitus in liver cirrhosis

AA Haji-Agha-Mohammadi; Y Mohammadikebar; A Ziaei; N Mohammadi; A Javadi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

Authors Guide Submit Manuscript

Comparison of fasting glucose and oral glucose tolerance tests in diagnosis of diabetes mellitus in liver cirrhosis

Author(s):

AA Haji-Agha-Mohammadi^,*,

Y Mohammadikebar,

A Ziaei,

N Mohammadi,

A Javadi

Journal of Inflammatory Diseases:Vol. 14, issue 4; 12-16

Published online:Mar 31, 2011

Article type:Research Article

How to Cite:Haji-Agha-Mohammadi A, Mohammadikebar Y, Ziaei A, Mohammadi N, Javadi A. Comparison of fasting glucose and oral glucose tolerance tests in diagnosis of diabetes mellitus in liver cirrhosis. J Inflamm Dis. 2024;14(4):e155565. doi:

Abstract

Background: Diabetes mellitus (DM) and glucose intolerance are commonly associated with liver cirrhosis and considered as important prognostic factors in liver cirrhosis. Objective: To determine the more sensisitive test for diagnosis of diabetes mellitus in liver cirrhosis. Methods: A total of 92 patients with liver cirrhosis were enrolled in a descriptive-analytic study. The levels of FBS and blood sugar two hours after ingestion of 75gr glucose (OGTT) were measured. FBS and 2-hPG concentrations were analysed for all subjects. Chi-square test and Fisher's exact test were used to analyse the data and p values <0.05 were considered as significant. Findings: A total of 92 cirrhotic cases with mean age of 54.1±14.1 years were enrolled in this study of which 51 cases were males (55.4%) and 41 females (44.6%). Using FBS measurement test, DM was diagnosed in 14 subjects (15.2%), impaired fasting glucose (IFG) in 16 subjects (17.4%), and normal fasting glucose in 62 subjects (67.4%). However, when OGTT was employed, DM found to be present in 36 subjects (39.1%), impaired glucose tolerance (IGT) in 26 subjects (28.3%), and normal glucose tolerance (NGT) in 30 subjects (32.6%). Comparison of FBS and OGTT (as gold standard test) showed that there was a significant difference between two tests (p<0.001). The sensitivity of FBS test to diagnose DM was 46.7% with a specificity of 96.7 %. The P.P.V and NPV were 96.7% and 46.7%, respectively. The FBS cut off was estimated at 83.50 mg/dl. Conclusion: The determination of FBS level seems to be insufficient in detecting DM in patients with liver cirrhosis. Thus, in addition to FBS measurement, the OGTT, as a routine test for cirrhosis, is recommended.

Keywords

Liver Cirrhosis

Diabetes Mellitus

Fasting Plasma Glucose

Oral Glucose Tolerance Test

Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease

A Gharavi,

AA Hajagha Mohammadi,

A Ziaee,

MR Sarookhani,

A Javadi,

S Haghazali

Gharavi A, Hajagha Mohammadi A, Ziaee A, Sarookhani M, Javadi A, et al. Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease. J Inflamm Dis. 2024;12(1):e155374. doi:

27

Jun

2023

Is There any Need for the Early Detection of Non-alcoholic Fatty Liver Disease in Children with Type 1 Diabetes Mellitus?

Soodeh Salehi,

Sanaz Mehrpour,

Shahin Koohmanaee,

Shohreh Maleknejad,

Mohammad Ali Esfandiari,

Saman Maroufizadeh

,et al.

Salehi S, Mehrpour S, Koohmanaee S, Maleknejad S, Esfandiari MA, et al. Is There any Need for the Early Detection of Non-alcoholic Fatty Liver Disease in Children with Type 1 Diabetes Mellitus?. Hepat Mon. 2023;23(1):e135941. doi: https://doi.org/10.5812/hepatmon-135941

30

Apr

2007

Predictors of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes

F Hosseinpanah,

M Rambod,

L Sadeghi

Hosseinpanah F, Rambod M, Sadeghi L. Predictors of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes. Int J Endocrinol Metab. 2007;5(2):. doi:

16

Nov

2021

Low Vitamin D Level was Associated with Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Vahid Sheikhi,

Zahra Heidari

Sheikhi V, Heidari Z. Low Vitamin D Level was Associated with Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus. Shiraz E-Med J. 2022;23(3):e118125. doi: https://doi.org/10.5812/semj.118125

2

Aug

2023

Predictors for Liver Cirrhosis in Patients with Hepatitis C Virus: A Cross-Sectional Study

Abolfazl Namazi,

Pouya Ebrahimi,

Arash Sarveazad,

Mohsen Khaleghian,

Mansour Bahardoust,

Marjan Mokhtare

,et al.

Namazi A, Ebrahimi P, Sarveazad A, Khaleghian M, Bahardoust M, et al. Predictors for Liver Cirrhosis in Patients with Hepatitis C Virus: A Cross-Sectional Study. Hepat Mon. 2023;23(1):e136164. doi: https://doi.org/10.5812/hepatmon-136164

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 0
Last Update: 1 week ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

AA Haji-Agha-Mohammadi:[PubMed][Scholar]
Y Mohammadikebar:[PubMed][Scholar]
A Ziaei:[PubMed][Scholar]
N Mohammadi:[PubMed][Scholar]
A Javadi:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

Comparison of fasting glucose and oral glucose tolerance tests in diagnosis of diabetes mellitus in liver cirrhosis

Abstract

Similar Articles

Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease

Is There any Need for the Early Detection of Non-alcoholic Fatty Liver Disease in Children with Type 1 Diabetes Mellitus?

Predictors of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes

Low Vitamin D Level was Associated with Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Predictors for Liver Cirrhosis in Patients with Hepatitis C Virus: A Cross-Sectional Study

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 3 days ago