Association between vitamin D receptor Apa1 and Taq1 genes polymorphism and osteoporosis in postmenopausal women

M abassi; SH Hassani; H. Sheikholeslami; SA Alizadeh; Z Rashvand; Z Yazdi; R Najafipour

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Association between vitamin D receptor Apa1 and Taq1 genes polymorphism and osteoporosis in postmenopausal women

Author(s):

M abassi^,*,

SH Hassani,

H. Sheikholeslami,

SA Alizadeh,

Z Rashvand,

Z Yazdi,

R Najafipour^1,**

1Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Corresponding Authors:

Journal of Inflammatory Diseases:Vol. 16, issue 3; 4-10

Published online:Dec 31, 2012

Article type:Research Article

How to Cite:abassi M, Hassani S, Sheikholeslami H, Alizadeh S, Rashvand Z, et al. Association between vitamin D receptor Apa1 and Taq1 genes polymorphism and osteoporosis in postmenopausal women. J Inflamm Dis. 2024;16(3):e155703. doi:

Abstract

Background: Osteoporosis is the commonest systemic disease leading to increased bone fragility and fracture. Vitamin D receptor Polymorphism is thought to have the most genetic influence on BMD. Objective: The aim of this study was to investigate the association between vitamin D receptor Apa1 and Taq1 genes polymorphism and osteoporosis in postmenopausal women. Methods: This was a case/control study in which 80 patients with osteoporosis (case group), referred to rheumatology ward at Boalisina Hospital during 2010 were investigated. The control group included an equal number of patients who visited other wards of the hospital for a variety of reasons. We obtained the bone mass densitometry (grams per centimeter square) results of case and control groups at the lumbar spine, wrist and hip by dual-energy X-ray absorptiometry. The distribution of Apa1 and Taq1 polymorphism in the VDR gene was determined by PCR-RFLP. Data were statistically analyzed by SPSS software using chi-square and ANOVA tests. Findings: There was no relationship between the Apa1, Taq1 VDR polymorphism and BMD results. We found that patients with Taq1 genotype (tt) had lower bone mass in the femur and wrist compared with Tt. Conclusion: Based on our findings, a relationship between the VDR polymorphism and osteoporosis remains unclear requiring further in-depth studies. Our results showed that other secondary factors may influence the bone mass density.

Keywords

Keywords: Polymorphism

Vitamin D Genotype

Osteoporosis

Bone Marrow Density

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Mohammad Hossein Dabbaghmanesh,

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Montazeri-Najafabady N, Dabbaghmanesh MH, Mohammadian Amiri R, Akbarzadeh M. Association of Vitamin D Receptor BsmI Gene Polymorphism with BMD Z-Score in Iranian Children and Adolescents (9 - 18 Years Old). Int J Endocrinol Metab. 2019;17(2):e82677. doi: https://doi.org/10.5812/ijem.82677

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Nair S, Bhadricha H, Hatkar S, Kadam SS, Patil A, et al. Effect of Vitamin D Levels on Bone Remodeling in Healthy Women. Int J Endocrinol Metab. 2020;18(2):e100656. doi: https://doi.org/10.5812/ijem.100656

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Gene Variants of Vitamin D Receptor (TaqI T > C (rs731236) and BsmI G > A (rs1544410) in Urolithiasis

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Seyedzadeh A, Rahimi Z, Tohidi MR, Soraya N. Gene Variants of Vitamin D Receptor (TaqI T > C (rs731236) and BsmI G > A (rs1544410) in Urolithiasis. J Kermanshah Univ Med Sci. 2024;28(2):e143931. doi: https://doi.org/10.5812/jkums-143931

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Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects

M Abbasi,

Z Rezaie Yazdi,

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MR Hatef,

M Sahebari,

M Yarjanli

Abbasi M, Rezaie Yazdi Z, Tavakol Afshari J, Hatef M, Sahebari M, et al. Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects. J Inflamm Dis. 2024;13(1):e155450. doi:

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Correlation between bone mineral density and osteoporosis With Ca and vitamin D intake

e Javadi,

A Hossein-nezhad,

Alireza Khalili-Fard,

h Adibi,

J Maghbooli,

b Larijani

Javadi E, Hossein-nezhad A, Khalili-Fard A, Adibi H, Maghbooli J, et al. Correlation between bone mineral density and osteoporosis With Ca and vitamin D intake. Zahedan J Res Med Sci. 2003;5(1):e95137. doi:

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Author(s):

M abassi:[PubMed][Scholar]
SH Hassani:[PubMed][Scholar]
H. Sheikholeslami:[PubMed][Scholar]
SA Alizadeh:[PubMed][Scholar]
Z Rashvand:[PubMed][Scholar]
Z Yazdi:[PubMed][Scholar]
R Najafipour:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

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Association between vitamin D receptor Apa1 and Taq1 genes polymorphism and osteoporosis in postmenopausal women

Abstract

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