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Jundishapur Journal of Microbiology
Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2008-4161
p-ISSN 2008-3645
Prevalence of anti hepatitis B surface antibody among children in Ahvaz, Iran, five years after vaccination
Authors
1Jundishapur Infectious and Tropical Diseases Research Centre, and Abuzar Childrens Hospital, Ahvaz Jundishapur University of Medical Sciences, Shamsizadeh@ajums.ac.ir, Iran
2Jundishapur Infectious and Tropical Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Iran
*Corresponding Author: Jundishapur Infectious and Tropical Diseases Research Centre, and Abuzar Childrens Hospital, Ahvaz Jundishapur University of Medical Sciences, Shamsizadeh@ajums.ac.ir, Iran. Tel: +98611 2215365. Fax: +98611 444711. Email: Shamsizadeh@ajums.ac.ir
Jundishapur Journal of Microbiology:Vol. 4, issue 1
Published online:Jan 31, 2011
Article type:Research Article
How to Cite:Shamsizadeh A, Makvandi M, Shoshtari G. Prevalence of anti hepatitis B surface antibody among children in Ahvaz, Iran, five years after vaccination. Jundishapur J Microbiol. 2011;4(1):. doi:
Abstract
Introduction and objective: The public vaccination program of hepatitis B virus was started in 1993 in Iran, and all children received three doses of hepatitis B vaccine in 0, 2 and 6 months of age routinely. The objective of this study was to determine the prevalence of antibody to hepatitis B surface (anti-HBs) five years after vaccination.
Materials and methods: In a cross-sectional study, anti-HBs was determined in six year old girl and boy students of selected elementary schools of Ahvaz with enzyme-linked immunosorbent assay (ELISA) method in 2006. All children had received complete course of hepatitis B vaccination in the first year of age.
Results: Four hundred and twenty seven students (223 girls and 204 boys) were enrolled in the study. Of them, 75.4% were anti-HBs positive (>10 mIU/mL). The prevalence of anti-HBs was statistically different between males and females (P=0.02).
Conclusion: The study detected anti-HBs in 75.4% of children and because of possibility of presence of anamnestic responses in seronegative subjects, a booster dose of vaccine is not necessary at least five years after primary vaccination. Further studies are needed to evaluate hepatitis B immunity in older age groups.
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Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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