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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT
Authors
1Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, [email protected], Iran
2Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, Iran
3Institute of Biophysics and Biochemistry, Tehran University, Iran
*Corresponding Author: Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, [email protected], Iran. Email: [email protected]
Published online:Mar 30, 2007
Article type:Research Article
Received:Feb 21, 2006
Accepted:Jul 20, 2007
How to Cite:Arzi A, Hemmati A, Ghobishavi S, Arzi L. THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT. Jundishapur J Nat Pharm Prod. 2007;2(1):. doi:
Abstract
Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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